冠心病患者冠状动脉循环氧化低密度脂蛋白水平与内皮损伤的关系The relationship between oxidized LDL and coronary endothelial dysfunction in patients with coronary heart disease
董红梅,黄岚,晋军,武晓静,赵刚,宋耀明,李爱民,覃军,耿召华,宋明宝
摘要(Abstract)：
目的探讨冠心病患者氧化低密度脂蛋白(ox-LDL)变化与冠状动脉(冠脉)内皮损伤及相关临床表现的关系。方法54例冠心病患者均经冠脉造影证实有明显冠脉狭窄,测定其冠状窦和外周血中ox-LDL、一氧化氮(NO)及循环内皮细胞(CEC)数量,分为不稳定型心绞痛(UA)组和稳定型心绞痛(SA)组,比较两组与正常对照组(20例)间相同和不同部位之间指标的差异。结果UA组、SA组患者冠状窦血中NO含量较对照组明显降低,ox-LDL和CEC均明显增高。冠状窦血中NO含量均明显低于外周血,ox-LDL和CEC均明显高于外周血。对照组冠状窦与外周血相比三项指标均未见明显差别。结论冠心病患者冠脉局部ox-LDL升高与冠脉内皮损伤相关,并与冠心病病情严重程度一致,可能参与了冠心病病情恶化以及急性冠脉事件的发生。
关键词(KeyWords)： 冠状动脉疾病;脂蛋白类,LDL;内皮
基金项目(Foundation): 国家自然科学基金项目(30470729)
作者(Author): 董红梅,黄岚,晋军,武晓静,赵刚,宋耀明,李爱民,覃军,耿召华,宋明宝
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