徐剑刚,李康,张劲林,王祖禄

• 1:美敦力(上海)管理有限公司
• 2:北京大学第一医院心内科
• 3:武汉亚洲心脏病医院心内科
• 4:中国人民解放军北部战区总医院心内科

摘要(Abstract)：

经导管脉冲电场消融（PFA）治疗心房颤动在全球得到广泛的临床应用，积累了大量有效性和安全性的临床证据，近年来也观察到一些与该技术相关的不良事件，如消融相关的冠状动脉痉挛、溶血及术后急性肾功能损伤、术后无症状或症状性脑血管事件等。本文结合近两年PFA的最新基础和临床研究进展，从脉冲电场的场强阈值、PFA的热效应、接触力和消融次数等生物物理学效应方面对PFA是否具有组织选择性，溶血和微泡的发生机制，损伤的形态和深度等进行阐述，以期帮助临床医师更全面地了解和应用PFA技术。

关键词(KeyWords)： 心房颤动;脉冲电场消融;溶血;微泡

Abstract:

Keywords:

基金项目(Foundation):

作者(Author): 徐剑刚,李康,张劲林,王祖禄

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