血管内皮生长因子基因治疗缺血性疾病的机制和研究现状
田菁,吕树铮
摘要(Abstract)：
关键词(KeyWords)：
基金项目(Foundation):
作者(Author): 田菁,吕树铮
参考文献(References)：
- 1AchenMG ,StackerSA .Thevascularendothelialgrowthfactorfamily:proteinswhichguidethedevelopmentofthevasculature.IntJExpPath,1998,79:255265.
- 2ValePR ,LosordoDW ,MillikenCE ,etal.ImagesinCardiovascularMedicine:PercutaneousmyocardialgenetransferofphVEGF 2.Circulation,1999,100(24):24622463.
- 3ValePR ,LosordoDW ,MillikenCE ,etal.ImagesinCardiovascularMedicine:PercutaneousmyocardialgenetransferofphVEGF 2.Circulation,1999,100:24622463.
- 4BanaiS ,ShweikiD ,PinsonA ,etal.Upregulationofvascularendothelialgrowthfactorexpressioninducedbymyocardialischemia:implicationsforcoronaryangiogenesis.CardiovascRes,1994,28:11761179.
- 5GuJW ,AdairTH .Hypoxia inducedexpressionofVEGFisreversibleinmyocardialvascularsmoothmusclecells.AmJPhysiol,1997,273(2pt2):H628633.
- 6张曼,沈乐,周爱儒.缺氧条件下血管活性因子对血管内皮细胞中VEGF表达的影响.中国生物化学与分子生物学报,2001,17:121123.
- 7LiJ,BrownLF ,HibberdMG ,etal.VEGF ,flk1,andflt1expressioninaratmyocardialinfartionmodelofangiogenesis.AmJPhysiol,1996,270(5pt2):H18031811.
- 8SellkeFW ,WangSY ,StamlerA ,etal.EnhancedmicrovascularrelaxationtoVEGFandbFGFinchronicallyischemicporcinemyocardium.AmJPhysiol,1996,271(2pt2):H713720.
- 9KranzA ,RauC ,KochsM ,etal.ElevationofvascularendothelialgrowthfactorAserumlevelsfollowingacutemyocardialinfarction.Evidenceforitsoriginandfunctionalsignificance.JMolCellCardiol,2000,32:6572.
- 10OgawaH ,SuefujiH ,SoejimaH ,etal.Increasedbloodvascularendothelialgrowthfactorlevelsinpatientswithacutemyocardialinfarction.Cardiology,2000,93:9399.
- 11IkedaE ,AchenMG ,BreierG ,etal.Hypoxia inducedtranscriptionalactivationandincreasedmRNAstabilityofvascularendothelialgrowthfactorinC6gliomacells.JBiolChem,1995,270:1976119766.
- 12LevyNS ,ChungS ,FurneauxH ,etal.HypoxicstabilizationofvascularendothelialgrowthfactormRNAbytheRNA bindingproteinHuR .JbiolChem,1998,273:64176423.
- 13GerberHP ,DixitV ,FerraraN .VascularendothelialgrowthfactorinducesexpressionoftheantiapoptoticproteinsBcl2andA1invascularendothelialcells.JBiolChem,1998,273:1331313316.
- 14WangH ,KeiserJA .Vascularendothelialgrowthfactorupregulatestheexpressionofmatrixmetalloproteinasesinvascularsmoothmusclecells:roleofflt1.CircRes,1998,83:832840.
- 15BarleonB ,SozzaniS ,Zhoud,etal.Migrationofhumanmonocytesinresponsetovascularendothelialgrowthfactor(VEGF)ismediatedviatheVEGFreceptorflt1.Blood,1996,87:33363343.
- 16TakeshitaS ,TsurumiY ,CouffinahlT ,etal.GenetransferofnakedDNAencodingforthreeisoformsofvascularendothelialgrowthfactorstimulatescollateraldevelopmentinvivo.LaboratoryInves,1996,Vol75,No.4:487501.
- 17Yukioetal.Treatmentofacutelimbischemiabyintramuscularinjectionofvascularendothelialgrowthfactor.Circulation,1997,96:Ⅱ382388.
- 18SatoshiTakeshita,TakaakiIsshiki,MasahikoOchiai,etal.EndotheliumDependentRelaxationofCollateralMicrovesselsAfterIntramuscularGeneTransferofVascularEndothelialGrowthFactorinaRatModelofHindlimbIschemia.Circulation,1998,98:12611263.
- 19郑卫,霍勇,邢德智等.血管内皮生长因子基因治疗犬闭塞性血管病的初步研究.中华心血管病杂志,1998:12:46.
- 20盛琴慧,朱国英,周爱儒等.血管内皮生长因子基因治疗肢体动脉梗塞病的实验研究.中华医学杂志,1999,79:129132.
- 21IsnerJM ,PieczekA ,SchainfeldR ,etal.ClinicalevidenceofangiogenesisafterarterialgenetransferofphVEGF165inpatientwithischaemiclimb.Lancet,1996,348:370374.
- 22IrisBaumgartner,AnnPieczek,OritManor,etal.ConstitutiveExpressionofphVEGF165AfterIntramuscularGeneTransferPromotesCollateralVesselDevelopmentinPatientsWithCriticalLimbIschemiaCirculation,1998,97:11141123.
- 23MackC ,PatelS ,SchwarzE ,etal.Biologicbypasswiththeuseofadenovirus mediatedgenetransferofthecomplementarydeoxyribonucleicacidforvascularendothelialgrowthfactor121improvesmyocardialperfusionandfunctionintheischemicporcineheart.JThoracCardiovascSurg,1998,115:168177.
- 24RosengartT ,LeeL ,PatelS ,etal.Six monthassessmentofaphaseItrialofangiogenicgenetherapyforthetreatmentofcoronaryarterydiseaseusingdirectintramyocardialadministrationofanadenovirusvectorexpressingtheVEGF121cDNA .AnnSurg,1999,230:466472.
- 25刘艳秋,周爱儒,朱小君,等.大鼠心肌缺血的血管内皮生长因子基因治疗.北京医科大学学报,1999,31:489492.
- 26TioRA ,TkebuchavaT ,ScheuermannTH ,etal.IntramyocardialgenetherapywithnakedDNAencodingvascularendothelialgrowthfactorimprovescollateralflowtoischemicmyocardium.HumGeneTher,1999,10:29532960.
- 27LosordoDW ,ValePR ,SymesJM ,etal.Genetherapyformyocardialangiogenesis,initialclinicalresultswithdirectmyocardialinjectionofphVEGF165assoletherapyformyocardialischemia.Circulation,1998,98:28002804.
- 28熊一力,蒋薛俊,陆再英等.经球囊导管冠脉内VEGF基因转移对犬心肌更新供血的作用.实用临床医学,1998,12:46.
- 29LazarousDF ,ShouM ,StiberJA ,etal.Adenoviral mediatedgenetransferinducessustainedpericardialVEGFexpressionindogs:effectonmyocardialangiogenesis.CardiovascRes1999,44(2):294302.
- 30KornowskiR ,LeonMB ,FuchsS ,etal.Electromagneticguidanceforcatheter basedtransendocardialinjection:aplatformforintramyocardialangiogenesistherapy.Resultsinnormalandischemicporcinemodels.JAmCollCardiol2000,35(4):10311039.
- 31刘艳秋,周爱儒,牛大地,等.血管内皮生长因子基因治疗大鼠脑缺血的实验研究.中国生物化学与分子生物学学报,1999,15:681686.
- 32TakayukiAsahara,ChristopheBauters,ChristopherPastore,etal.LocalDeliveryofVascularEndothelialGrowthFactorAcceleratesReendothelializationandAttenuatesIntimalHyperplasiainBalloonInjuredRatCarotidArtery.Circulation,1995,91:27932810.
- 33VanBelleE ,TioFO ,ChenD ,etal.PassivationofmetallicstentsafterarterialgenetransferofphVEGF165inhibitsthrombusformationandintimalthickening.JAmCollCardiol,1997,29:13711379.