陈旧性前壁心肌梗死患者自体骨髓单个核细胞移植后左室心肌灌注及收缩功能的变化Effects of autologous mononuclear bone marrow cells transplantation on the cardiac function and myocardial perfusion in patients with old myocardial infarction
葛均波,李延林,钱菊英,史剑慧,王齐兵,牛玉宏,潘翠珍,樊冰,黄国倩,刘学波
摘要(Abstract)：
目的 评价经冠状动脉内自体骨髓单个核细胞移植对陈旧性心肌梗死患者心功能和心肌灌注的影响及其安全性。方法与结果 入选 10例陈旧性前壁心肌梗死患者 ,在冠状动脉造影和介入治疗后 ,经冠状动脉内灌注导管将自体骨髓单个核细胞缓慢注入前降支。随访 3个月后 ,左室射血分数由术前 4 5 3%± 9 8%升高至 5 4 5 %± 6 5 % (P =0 0 0 3) ;2 0 1 Tl心肌灌注显像 (SPECT)显示左心室心肌灌注明显改善 ,即刻和延迟心肌灌注评分分别由术前的 2 9 5± 5 8和 2 8 6± 6 3降低至 2 3 9±5 7和 2 3 0± 6 1(P均 <0 0 1) ,没有手术有关的并发症和恶性心律失常发生。结论 陈旧性前壁心肌梗死患者经冠状动脉内自体骨髓单个核细胞移植 ,可显著改善左室收缩功能和心肌灌注 ,并且具有良好的临床操作安全性。
关键词(KeyWords)： 心肌梗死;骨髓细胞;心脏功能
基金项目(Foundation):
作者(Author): 葛均波,李延林,钱菊英,史剑慧,王齐兵,牛玉宏,潘翠珍,樊冰,黄国倩,刘学波
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