崔婷,孙万峰,施展,张国培,石颖秋,顾行军

• 1:盐城市第三人民医院心内科

摘要(Abstract)：

目的观察经胸左心耳穿刺入径置入自制左心耳封堵器夹闭左心耳的可行性、安全性和有效性。方法选用健康、成年犬12只,使用自主研制的镍钛合金左心耳封堵器经胸左心耳穿刺入径行左心耳夹闭术。术后1周(1只)、1个月(2只)、3个月(2只)、6个月(2只)、1年(4只)分别通过心脏超声、心脏大体标本观察及光镜检查等,评价经胸左心耳穿刺置入自制左心耳封堵器的可行性、安全性及封堵器置入后内皮化过程。结果实验犬左心耳封堵器置入成功率为91.7%,1只犬在封堵器置入后因空气栓塞致心室颤动死亡。术后1周、1个月、3个月、6个月、1年分别处死实验犬,心脏大体标本观察显示封堵器未见移位,封堵器表面未见血栓形成和赘生物附着。术后1周封堵器左心房、左心耳侧盘面均未见明显组织覆盖;术后1个月封堵器左心房侧盘面可见光滑平整的薄层组织覆盖,病理证实为纤维组织和内皮细胞,封堵器边缘与周围心房壁部分融合,左心耳侧盘面与心包无粘连,可见部分纤维组织包绕;术后3个月、6个月、1年封堵器左心房侧盘面光整,覆盖组织增厚,封堵器边缘与周围心房壁完全融合,左心耳侧盘面光整,完全被纤维组织包绕。结论经胸穿刺左心耳入径置入自制封堵器封闭左心耳的方法简单、安全、有效。

关键词(KeyWords)： 左心耳穿刺;左心耳封堵器;犬;内皮化

Abstract:

Keywords:

基金项目(Foundation):

作者(Author): 崔婷,孙万峰,施展,张国培,石颖秋,顾行军

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