盛兆雪,谭宇,周鹏,刘臣,李健楠,周金英,陈润真,陈艺,宋莉,赵汉军,颜红兵

• 1:国家心血管病中心北京协和医学院中国医学科学院阜外医院冠心病中心

摘要(Abstract)：

目的探讨急性心肌梗死斑块破裂人群血浆氧化三甲胺(TMAO)水平与罪犯斑块易损特征的关系。方法连续入选中国医学科学院阜外医院2017年4月1日至2018年7月31日因急性心肌梗死行直接经皮冠状动脉介入治疗并行光学相干断层成像(OCT)检查后证实斑块破裂的90例患者。搜集患者人口学资料、危险因素、既往病史、围术期实验室检查结果、冠状动脉造影资料和OCT影像特征资料。使用稳定同位素稀释-高效液相色谱-串联质谱法测定患者的血浆TMAO水平,根据TMAO中位数(3.22μmol/L)水平将入选患者分为TMAO高值组(45例)和TMAO低值组(45例)。使用归一化标准差(NSD)定量评估罪犯斑块巨噬细胞浸润程度。结果与TMAO低值组患者相比,TMAO高值组患者最小纤维帽厚度更薄[60.00(60.00,100.00)μm比90.00(70.00,110.00)μm,P=0.013],而薄纤维帽斑块比例(55.6%比15.6%,P<0.001)、微通道比例(24.4%比4.4%,P=0.014)和巨噬细胞浸润比例(66.7%比26.7%,P<0.001)更高。TMAO水平与反映罪犯斑块巨噬细胞浸润程度的NSD呈显著正相关(Pearson’s r=0.542,P<0.001)。结论在由斑块破裂导致急性心肌梗死患者中血浆TMAO与罪犯斑块的易损性相关。TMAO可以作为反映冠状动脉斑块易损性的潜在生物标志物,从而优化急性心肌梗死患者危险分层方法和临床治疗策略。

关键词(KeyWords)： 急性心肌梗死;光学相干断层成像;斑块破裂;氧化三甲胺

Abstract:

Keywords:

基金项目(Foundation): 中国医学科学院医学与健康科技创新工程基金(2016-I2M-1-009、NCT03593928)

作者(Author): 盛兆雪,谭宇,周鹏,刘臣,李健楠,周金英,陈润真,陈艺,宋莉,赵汉军,颜红兵

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