持续性心房颤动线性消融及不同阻滞线与复发的关系分析Prognosis of patients with persistent atrial fibirllaiton in relation to left atrial linear ablation and different blocked lines
杨国澍,蔡琳,王新华,施海峰,谭红伟,姜伟峰,顾佳宁,李峥,刘旭
摘要(Abstract):
目的探索持续性心房颤动线性消融及不同阻滞线与临床复发之间的关系。方法入选2009年5月至2010年7月因持续性房颤首次行导管射频消融术的患者440例。年龄(61±10)岁,男性308例,房颤病程(4.1±5.1)年。在CARTO三维标测系统引导下行环同侧肺静脉前庭电隔离术、心房复杂碎裂电位消融术及必要的线性消融。结果 440例患者均顺利完成射频消融术,142例(32.3%)行线性消融达双向阻滞(线性消融组),298例(67.7%)未行线性消融(非线性消融组)。线性消融组中房顶阻滞线85例(59.9%),二尖瓣峡部线阻滞18例(12.7%),二尖瓣峡部和房顶阻滞线均达双向阻滞39例(27.4%)。术后随访(18.4±5.1)月,消融次数1(1~3)次。线性消融组122例(85.9%)未见复发;非线性消融组225例(75.5%)未见复发(P=0.012)。亚组分析房顶线消融组74例(87.1%)未见复发,二尖瓣峡部线消融组15例(83.3%)未见复发,房顶线和二尖瓣峡部线消融组33例(84.6%)未见复发,两两组间比较差异无统计学意义。结论左心房线性消融并达双向阻滞能进一步提高消融成功率;左心房内不同的消融阻滞线对复发的影响需要更深更广泛的探讨。
关键词(KeyWords): 心房颤动;导管消融术;复发
基金项目(Foundation):
作者(Author): 杨国澍,蔡琳,王新华,施海峰,谭红伟,姜伟峰,顾佳宁,李峥,刘旭
参考文献(References):
- [1]Nademanee K,McKenzie J,Kosar E,et al.A new approach for catheter ablation of atrial fibrillation:mapping of the electrophysiologic substrate.J Am Coll Cardiol,2004,43:2044-2053.
- [2]Nademanee K,Schwab MC,Kosar EM,et al.Clinical outcomes of catheter substrate ablation for high-risk patients with atrial fibrillation.J Am Coll Cardiol,2008,51:843-849.
- [3]O'Neill MD,Wright M,Knecht S,et al.Long-term follow-up of persistent atrial fibrillation ablation using termination as a procedural endpoint.Eur Heart J,2009,30:1105-1112.
- [4]Verma A,Mantovan R,Macle L,et al.Substrate and Trigger Ablation for Reduction of Atrial Fibrillation(STAR AF):a randomized,multicentre,international trial.Eur Heart J,2010,31:1344-1356.
- [5]Rostock T,Steven D,Hoffmann B,et al.Chronic atrial fibrillation is a biatrial arrhythmia:data from catheter ablation of chronic atrial fibrillation aiming arrhythmia termination using a sequential ablation approach.Circ Arrhythm Electrophysiol,2008,1:344-353.
- [6]Fassini G,Riva S,Chiodelli R,et al.Left mitral isthmus ablation associated with PV Isolation:long-term results of a prospective randomized study.J Cardiovasc Electrophysiol,2005,16:1150-1156.
- [7]Hocini M,Jas P,Sanders P,et al.Techniques,evaluation,and consequences of linear block at the left atrial roof in paroxysmal atrial fibrillation:a prospective randomized study.Circulation,2005,112:3688-3696.
- [8]Knecht S,Hocini M,Wright M,et al.Left atrial linear lesions are required for successful treatment of persistent atrial fibrillation.Eur Heart J,2008,29:2359-2366.
- [9]Senga M,Fujii E,Sugiura S,et al.Efficacy of linear block at the left atrial roof in atrial fibrillation.J Cardiol,2010,55:322-327.
- [10]Jas P,Hocini M,Hsu LF,et al.Technique and results of linear ablation at the mitral isthmus.Circulation,2004,110:2996-3002.
- [11]Nishida K,Sarrazin JF,Fujiki A,et al.Roles of the left atrial roof and pulmonary veins in the anatomic substrate for persistent atrial fibrillation and ablation in a canine model.J Am Coll Cardiol,2010,56:1728-1736.
- [12]Becker AE.Left atrial isthmus:anatomic aspects relevant for linear catheter ablation procedures in humans.J Cardiovasc Electrophysiol,2004,15:809-812.
- [13]Ho SY,Sanchez-Quintana D,Cabrera JA,et al.Anatomy of the left atrium:implications for radiofrequency ablation of atrial fibrillation.J Cardiovasc Electrophysiol,1999,10:1525-1533.
- [14]Calkins H,Kuck KH,Cappato R,et al.2012HRS/EHRA/ECAS Expert Consensus Statement on Catheter and Surgical Ablation of Atrial Fibrillation:recommendations for patient selection,procedural techniques,patient management and follow-up,definitions,endpoints,and research trial design.Europace,2012,14:528-606.
- [15]Senatore G,Stabile G,Bertaglia E,et al.Role of transtelephonic electrocardiographic monitoring in detecting short-term arrhythmia recurrences after radiofrequency ablation in patients with atrial fibrillation.J Am Coll Cardiol,2005,45:873-876.
- [16]Oral H,Veerareddy S,Good E,et al.Prevalence of asymptomatic recurrences of atrial fibrillation after successful radiofrequency catheter ablation.J Cardiovasc Electrophysiol,2004,15:920-924.
- [17]Rostock T,O'Neill MD,Sanders P,et al.Characterization of conduction recovery across left atrial linear lesions in patients with paroxysmal and persistent atrial fibrillation.J Cardiovasc Electrophysiol,2006,17:1106-1111.