刘晓琴,谢航,曾浩炜,孙镜颜,苏林杰,张玉顺

• 1:西安交通大学第一附属医院结构性心脏病科

摘要(Abstract)：

目的 分析偏头痛患者中卵圆孔未闭（PFO）封堵术的中长期疗效。方法 收集2013年1月至2017年12月于西安交通大学第一附属医院结构性心脏病科诊断为PFO合并偏头痛，同时行PFO封堵术的患者，随访2年，比较术前及术后3个月、6个月、1年、2年的偏头痛发作频率、持续时间、头痛影响测验-6(HIT-6)评分、偏头痛残疾程度评价量表（MIDAS）评分及头痛视觉模拟量表（VAS）评分，评价PFO封堵治疗对PFO合并偏头痛患者的中长期获益，并探索影响偏头痛缓解的危险因素。结果 共193例患者入组本研究，随访术后各时间段偏头痛发作频率、持续时间、HIT-6评分、MIDAS评分及VAS评分均较术前明显改善，差异均有统计学意义（均P<0.001）。术后2年偏头痛完全缓解率为62.7%，有效率为92.2%。多因素Logistic回归分析显示术前存在静息状态下持续性右向左分流与术后长期偏头痛缓解率的降低相关（OR 0.462,95%CI 0.231～0.923,P=0.029）。结论 PFO封堵治疗可能显著改善偏头痛患者症状，使偏头痛患者可以从中获益。对术前存在静息状态下持续性右向左分流的患者应多加关注。

关键词(KeyWords)： 偏头痛;卵圆孔未闭;封堵治疗

Abstract:

Keywords:

基金项目(Foundation):

作者(Author): 刘晓琴,谢航,曾浩炜,孙镜颜,苏林杰,张玉顺

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