第二代双源CT双能量心肌灌注评价猪心肌梗死的实验研究The evaluation of myocardial infarction with dual-energy myocardial perfusion by using the second generation dual-source CT: an experimental study in pig phantom
赵瑞平,卢耀军,李洪宇,孙凯
摘要(Abstract):
目的评价第二代双源CT双能量心肌灌注"一站式"扫描得到的猪急性心肌梗死模型心肌灌注图像及冠状动脉图像的可行性和准确性。方法 5只猪行介入明胶海绵栓塞法建立猪急性心肌梗死模型。分别于造模前20 min及造模后24~48 h行"一站式"扫描和冠状动脉造影。检查结束后立即取出心脏多点取活检行苏木素-伊红(HE)染色,然后将心脏切成薄片行氯化三苯基四氮唑(TTC)染色。以冠状动脉造影及病理染色为金标准分别评价第二代双源CT双能量心肌灌注"一站式"扫描重建得到猪急性心肌梗死模型的冠状动脉图像及心肌灌注图像的敏感性、特异性。以Kappa检验分析结果的一致性。结果与病理金标准对比,"一站式"扫描得到心肌灌注碘图像的敏感性、特异性分别为93%、91%,Kappa值为0.82;与冠状动脉造影金标准对比,"一站式"扫描得到冠状动脉图像的敏感性、特异性分别为93%、81%,Kappa值为0.71。结论第二代双源CT双能量心肌灌注"一站式"扫描可以准确得到猪急性心肌梗死模型的冠状动脉图像及心肌灌注图像。
关键词(KeyWords): 心肌梗死;心肌灌注;第二代双源CT
基金项目(Foundation): 内蒙古自治区卫生和计划生育委员会科研立项项目(201302126);; 内蒙古自治区自然科学基金(2012MS1101)
作者(Author): 赵瑞平,卢耀军,李洪宇,孙凯
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