CORRELATION OF CAROTID ATHEROSCLEROSIS AND CORONARY ARTERY DISEASE AND THEIR RISK FACTORSCORRELATION OF CAROTID ATHEROSCLEROSIS AND CORONARY ARTERY DISEASE AND THEIR RISK FACTORS
Huang Zheng MD,Liu Yili,Gong Lansheng,Shi Zhangwei
摘要(Abstract)：
<正> Objectives.Relationship between carotid atherosclerosis(CAS) and severity ofcoronary artery disease(CAD) and different risk factors were investigated,Theseverity of CAD was tried to predict using carotid duplex scanning and riskfactors investigation.Methods.Carotid duplex scanning were performed in 103 patients who had beenconsecutively examined by coronary angiography.Patients were divided into 3groups(normal,I-vassal disease and multi-vessel disease group) according tocoronary angiographic results.To quantify the extent of CAS,maximal unicknessmeasurements of all plaques were summed for an individual plaque score.Gensini's CAD score was calculated to quantify the extent of coronary arteryatherosclerosis(CAAS),Relationship between carotid plaque score and extent ofCAAS was evaluated.Relationship between main risk factors and the degree ofatherosclerotic vascular involvement in carotid and coronary artery wasexamined using standard|sad partial correlation coefficients.Results.CAS plaques were more common in the bifurcation end in the left side.Intimal-medial thickness(IMT) of multi-vessel disease group was significantlylarger than that of the normal group(P<0.001).No significant differences werefound among these 3 groups with carotid Doppler parameters,A linearcorrelation between carotid duplex scanning parameters and carotid andcoronary atherosclerosis was found.Carotid plaque score was significantlyhigher in patients with l-vessel or multi-vessel CAD than that without significantCAD(P<0.001).There was e significant positive linear correlation betweencarotid plaque score and the extent of CAD(r=0.60,P<0.001).Age,male gender,smoking,hypertension,total cholesterol,LDL,plasma fibrinogen,and plateletaggregability were positively correlated with the extent of CAS and CAAS.HDLwas negatively correlated with CAS and CAAS.Formulas using carotid duplexscanning parameters and risk factors to predict the extent of CAD were provided.Contlusions.CAS was significantly correlated with the extent of CAAS.Age:male gender,smoking" hypertension,total cholesterol,LDL,plasma fibrinogen,and platelet aggregnbility were strong predictors for CAS and CAD.
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作者(Author): Huang Zheng MD,Liu Yili,Gong Lansheng,Shi Zhangwei