射频消融冠状窦的实验研究Catheter Ablation in Canine Coronary Sinus Using Radiofrequency Energy
任自文,兰玲,唐承珺,宋来凤,王方正,陈新,孙瑞龙
摘要(Abstract)：
对16条犬进行射频导管消融冠状静脉窦的作用及安全性研究.射频于冠状窦内电极导管和胸部片状电极间释放,能量为1229±711焦耳.13条犬于消融后半小时处死,3条犬于3～4周后处死.消融部位损伤长3.2±1.8mm,宽2.2±1.7mm,深2.±1.0mm,镜下所见为边界清晰的凝固性坏死(急性期)与纤维化(慢性期).冠状动脉、二尖瓣及心内膜均未受累.除二条犬偶发房性早搏或室性早搏外无心律失常发生,无血流动力学改变,无1例发生冠状静脉窦破裂.表明高能射频消融冠状静脉窦安全,就其损伤部位而论可能对破坏病人的左侧房室旁道有效.
关键词(KeyWords)： 射频;消融;冠状窦
基金项目(Foundation): 中国医学科学院国外特别科研基金
作者(Author): 任自文,兰玲,唐承珺,宋来凤,王方正,陈新,孙瑞龙
参考文献(References)：
- [1] Huang SKS,Graham A,Bharati S,et al.Short-and long-term effects of transcatheter ablation of the coronary sinus by radiofrequency energy.Circulation,1988,78(?):416．
- [2] Langberg J,Griffin JC,Herre JM,et al.Catheter ablation of accessory pathways using radiofrequency energy in the canine coronary sinus.JACC,1989,13(2) :491．
- [3] Becker AE,Anderson RH,Path MRC,et al.The anatomical substrates of Wolff-Parkinson-Wbite syndrome:a clinical-patbologic corrlation in seven patients.Circulation,1978,57:870．
- [4] Jackman W,Kuck KH,Naccarelli G,et al.Catheter ablation at the mitral annulus using radiofrequency current in canines(abstr).PACE,1987,10:410．
- [5] Kuck KH,Kunze KP,Schluter M,et al.Ablation of a left-sided free-wall accessory pathway by radioftequency current in a patient with the Wolff-Parkinson White syndrome.PACE,1989,12:1 681．
- [6] Hazan MB,Byrnes DA,Elmquist TH.et al.Angiographic demonstration of sinus thromosis:a potentisl consequency of trauma to the coronary sinus.Cathet Cardiovas Diagn,1982,8:405．
- [7] Hoyt RH,Huang SK,Jordan N,et al.Factors influencing transcatheter radiofrequency ablation of tbe myocardium(abstr).Circulation,1985,72(Suppl lII)III:473．