张书宁,孙爱军,葛均波,姚康,黄浙勇,王克强,邹云增

• 1:上海复旦大学附属中山医院心内科上海市心血管病研究所复旦大学细胞与组织工程中心

摘要(Abstract)：

目的系统评价经冠状动脉自体骨髓干细胞移植(BMSCs)对急性心肌梗死患者左心室功能的影响。方法检索PubMed、MEDLINE、中国期刊全文数据库等国内外数据库。以急性心肌梗死症状出现24h内成功实施再灌注治疗者为研究对象;试验设计体现随机对照原则;移植细胞种类为非动员的自体BMSCs;具有3个月以上左心室功能的随访资料。结果7项随机对照研究共纳入545人,平均随访4.9个月,BMSCs移植术后左心室射血分数(LVEF)较基线增加8.89%(95%CI3.42,14.36;P=0.001),与对照组相比,其绝对增量增加5.65%(95%CI2.24,9.06;P=0.001);移植组左心室舒张末容积/腔径基线测量值与随访值相比显示出更有利于基线的显著改变(P=0.01),且改善程度与对照组相比差异无统计学意义(标化均差-0.23;95%CI-0.59,0.12;P=0.20);移植组左心室收缩末容积/腔径较基线测量值无显著改变(标化均差-0.11;95%CI-0.32,0.11;P=0.33),而与对照组相比却显著缩小(标化均差95%CI-0.53,-0.09;P=0.005)。结论BMSCs移植治疗显著改善了心肌梗死后LVEF,并有效防止了左心室收缩末容积的不良增加,但未有效改善左心室心肌重构。

关键词(KeyWords)： 干细胞移植;心肌梗死;左心室功能;Meta分析

Abstract:

Keywords:

基金项目(Foundation): 国家重大科学研究计划(2006CB943704);; 上海市科委科研计划项目(06DJ14001);; 上海市医学领军人才培养计划(LJ06008)资助

作者(Author): 张书宁,孙爱军,葛均波,姚康,黄浙勇,王克强,邹云增

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