急性冠状动脉综合征支架置入与血小板活化的临床研究The clinical study of stent implantation and platelet activation in acute coronary syndrome
徐新生,沈彦明,宋建军,王竹文,苏洪山,李国平,王洪光,冯领周,周美辉
摘要(Abstract)：
目的探讨急性冠状动脉综合征(acute coronary syndrome,ACS)患者行冠状动脉(冠脉)内支架置入术前、后血小板活化指标的变化。方法利用流式细胞术(flowcytometry,FCM)和单克隆抗体测定45例不稳定型心绞痛(unstable angina pectoris,UAP)与37例急性心肌梗死(acute myocardial in-farction,AMI)患者外周血中血小板膜糖蛋白CD62p,CD63和凝血酶敏感蛋白(thrombin-sensitive protein,TSP)的阳性表达率,并与45例冠脉造影正常者相对照。结果FCM可简单、迅速地检测血小板的活化功能。ACS患者支架置入后CD62p,CD63和TSP的阳性表达率均显著高于支架置入前;ACS组治疗前亦高于对照组。结论急性冠脉综合征伴随血小板活化,介入治疗进一步加强血小板的活化。
关键词(KeyWords)： 冠状动脉疾病;血管成形术,经腔,经皮冠状动脉;支架
基金项目(Foundation):
作者(Author): 徐新生,沈彦明,宋建军,王竹文,苏洪山,李国平,王洪光,冯领周,周美辉
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