王智,唐强,唐群中,史振涛,陈学珠,王征

• 1:北京大学首钢医院心内科

摘要(Abstract)：

目的探讨急诊经皮冠状动脉介入治疗(PCI)前冠状动脉内注射血小板膜糖蛋白(GP)Ⅱb/Ⅲa受体拮抗剂盐酸替罗非班对急性ST段抬高型心肌梗死(STEMI)患者术中TIMI血流的影响。方法入选北京大学首钢医院2005年4月至2007年8月急性STEMI冠状动脉造影(CAG)显示梗死相关血管(IRA)有血栓征象的患者67例,其中男性48例,女性19例,平均年龄57.4±8.1岁,随机分成试验组(PCI前冠状动脉内注射盐酸替罗非班+PCI,n=35)与对照组(直接PCI,n=32)。收集所有病例的临床和CAG资料,对比两组患者PCI术中IRA的TIMI血流情况。结果试验组PCI术中无复流的发生率明显低于对照组(2.86%比18.75%,P<0.05),IRA远端栓塞发生率试验组明显低于对照组(0%比15.63%,P<0.05)。结论急诊PCI前冠状动脉内缓慢注射盐酸替罗非班可以明显改善急性STEMI患者急诊PCI术中IRA远端的前向血流,降低无复流现象的发生率。

关键词(KeyWords)： 心肌梗死;血管成形术,经腔,经皮冠状动脉;替罗非班

Abstract:

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基金项目(Foundation):

作者(Author): 王智,唐强,唐群中,史振涛,陈学珠,王征

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