崔鸣,颜利求,张永珍,王欣,张福春,牛杰,李海燕,王贵松,韩江莉,高炜,郭丽君

• 1:北京大学第三医院心内科
• 2:河北省沧州市中心医院

摘要(Abstract)：

目的探讨静息状态下冠脉狭窄远端压力与主动脉根部或冠脉口部压力的比值(Pd/Pa)与血流储备分数(FFR)之间的关系。方法回顾性分析在北京大学第三医院住院的84例患者中接受冠脉内压力导丝评估的103处病变的数据。多体位选择性冠脉造影,QCA评价病变直径狭窄程度。结果静息Pd/Pa值与FFR具有线性相关性(r=0.78;P<0.0001),以FFR值≤0.75来定义为缺血临界值时,当静息Pd/Pa≤0.86时,其预测缺血的阳性预测值可达95%,而当Pd/Pa值≥0.93时,其预测缺血阴性的预测值也达95%。结论静息Pd/Pa值与FFR具有明显的相关性,通过静息Pd/Pa值预测FFR缺血界值具有较高的阳性和阴性预测值,这提示在压力-病变功能评估中部分患者能够避免使用腺苷等微循环扩张剂,达到减少药物相关反应和手术过程的目的 。

关键词(KeyWords)： 压力导丝;冠脉临界病变;血流储备分数,心肌

Abstract:

Keywords:

基金项目(Foundation): 国家自然科学基金资助项目(81070260)

作者(Author): 崔鸣,颜利求,张永珍,王欣,张福春,牛杰,李海燕,王贵松,韩江莉,高炜,郭丽君

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