药物洗脱支架与冠状动脉内皮功能障碍
李丽,石铭宇,傅羽,尹新华,李为民,侯东明
摘要(Abstract):
<正>冠状动脉支架自问世已有30余年的历程,从金属裸支架(bare metal stent,BMS)到药物洗脱支架(drug eluting stent,DES),其在临床冠心病治疗中已经发挥了巨大作用。BMS的置入能够明显改善经皮冠状动脉腔内血管成形术后
关键词(KeyWords):
基金项目(Foundation): 中华医学会动脉粥样硬化专项基金(09010210176);; 黑龙江省科技攻关重大项目(GB08C402-02);; 黑龙江省杰出青年科学基金(JC201001)
作者(Author): 李丽,石铭宇,傅羽,尹新华,李为民,侯东明
参考文献(References):
- [1]Poredos P.Endothelial dysfunction in the pathogenesis of atherosclerosis.Int Angiol,2002,21:109-116.
- [2]Pendyala LK,Li J,Shinke T,et al.Endothelium-dependent vasomotor dysfunction in pig coronary arteries with paclitaxel-eluting stents is associated with inflammation and oxidative stress.J Am Coll Cardiol Interv,2009,2:253-262.
- [3]Jeanmart H,Malo O,Carrier M,et al.Comparative study of cyclosporine and tacrolimus vs newer immunosuppresants mycophenalate mofetil and rapamycin on the coronary endothelial function.J Heart Lung Transplant,2002,21:990-998.
- [4]Togni M,Raber L,Cocchia R,et al.Local vascular dysfunction after coronary paclitaxel-eluting stent implantation.Int J Cardiol,2007,120:212-220.
- [5]Togni M,Windecker S,Cocchia R,et al.Sirolimus-eluting stents associated with paradoxic coronary vasoconstriction.J Am Coll Cardiol,2005,46:231-236.
- [6]Kim JW,Suh SY,Choi CU,et al.Six-month comparison of coronary endothelial dysfunction associated with sirolimus-eluting stent versus paclitaxel-eluting stent.J Am Coll Cardiol Interv,2008,1:65-71.
- [7]Chen SL,Xu T,Zhang JJ,et al.Angioscopy study from a large patient population comparing sirolimus-eluting stent with biodegradable versus durable polymer.Catheter Cardiovasc Interv,2011,doi:10.1002/ccd.23306.
- [8]Akin I,Schneider H,Ince H,et al.Second-and third-generation drug-eluting coronary stents:progress and safety.Herz,2011,36:190-196.
- [9]Pendyala LK,Yin XH,Li JS,et al.The first-generation drug-eluting stents and coronary endothelial dysfunction.J Am Coll Cardiol Interv,2009,2:1169-1177.
- [10]Sahler LG,Davis D,Saad WE.Comparison of vasa vasorum after intravascular stent placement with sirolimus drug-eluting and bare metal stents.J Med Imaging Radiat Oncol,2008,52:570-575.
- [11]Gssl M,Rosol M,Malyar NM.Functional anatomy and hemodynamic characteristics of vasa vasorum in the walls of porcine coronary arteries.Anat Rec A Discov Mol Cell Evol Biol,2003,272:526-537.
- [12]Kim JW,Seo HS,Park JH,et al.A prospective,randomized,6-month comparison of the coronary vasomotor response associated with a zotarolimus-versus a sirolimus eluting stent.J Am Coll Cardiol,2009,53:1653-1659.
- [13]Hamilos M,Sarma J,Ostojic M.Interference of drug-eluting stents with endothelium dependent coronary vasomotion:evidence for device-specific responses.Circ Cardiovasc Interv,2008,1:193-200.
- [14]Joner M,Nakazawa G,Finn AV.Endothelial cell recovery between comparator polymer-based drug-eluting stents.J Am Coll Cardiol,2008,52:333-342.
- [15]Lange RA,Hillis LD.Second-generation drug-eluting coronary stents.N Engl J Med,2010,362:1728-1730.
- [16]Johnson TW,Wu YX,Herdeg C,et al.Stent-based delivery of tissue inhibitor of metalloproteinase-3adenovirus inhibits neointimal formation in porcine coronary arteries.Arterioscler Thromb Vasc Biol,2005,25:754-759.
- [17]Sharif F,Hynes SO,Cooney R.Gene-eluting stents adenovirus-mediated delivery of eNOS to the blood vessel wall accelerates re-endothelialization and inhibits restenosis.Mol Ther,2008,16:1674-1680.
- [18]Balla S,Aggarwal K,Nistala R.Bioabsorbable coronary stents-are these the next big thing in coronary angioplasty-Recent Pat Cardiovasc Drug Discov,2010,5:86-90.
- [19]Miyauchi K,Miyauchi T,Yokayama T,et al.Effectiveness of statin-eluting stent on early inflammatory response and neointimal thickness in a porcine coronary model.Circ J,2008,72:832-838.