冯培培,贺彤彤,刘学奎,郑义,王森,徐杜娟,娄明

• 1:徐州医科大学徐州临床学院
• 2:徐州市中心医院中心实验室
• 3:徐州市中心医院心内科
• 4:徐州市中心医院超声科

摘要(Abstract)：

目的 探讨阻塞性睡眠呼吸暂停低通气综合征（OSAHS）对高血压患者冠状动脉微循环功能的影响，并基于炎症因子水平的变化初步探讨其潜在机制。方法 连续纳入2024年9月至2025年11月于徐州市中心医院住院的93例患者，均于住院期间完成便携式睡眠监测与心脏负荷超声心动图检查。基于睡眠监测结果及高血压病史，将患者分为对照组、单纯高血压组、单纯OSAHS组[呼吸暂停低通气指数（AHI）≥5次/小时）]、高血压合并轻度OSAHS组（5次/小时≤AHI<15次/小时）及高血压合并中重度OSAHS组（AHI≥15次/小时）。收集所有受试者临床资料、睡眠参数、冠状动脉血流速度储备（CFVR）及超敏C反应蛋白（hs-CRP）、白细胞介素-6(IL-6)等指标。结果 93例患者平均年龄为（59.1±10.3）岁，其中男48例。高血压合并中重度OSAHS组与对照组、单纯高血压组、单纯OSAHS组及高血压合并轻度OSAHS组相比，CFVR显著降低（P<0.05）,hs-CRP分级3级、IL-6水平均显著增高（均P<0.05），差异均有统计学意义。Spearman相关性分析显示，CFVR与AHI、IL-6、hs-CRP分级呈负相关（均P<0.001）。多因素线性回归分析显示，AHI、最低血氧饱和度、氧减指数、呼吸暂停指数是CFVR下降的独立危险因素（均P<0.05）。结论 对于高血压患者，合并中重度OSAHS与更严重的冠状动脉微循环功能障碍相关，且伴随炎症标志物水平升高。

关键词(KeyWords)： 阻塞性睡眠呼吸暂停低通气综合征;高血压;冠状动脉微循环功能障碍;超敏C反应蛋白;白细胞介素-6

Abstract:

Keywords:

基金项目(Foundation): 江苏省第五批333高层次人才培养工程资助课题项目（BRA2020250）

作者(Author): 冯培培,贺彤彤,刘学奎,郑义,王森,徐杜娟,娄明

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