抗凝药物在心房颤动治疗中的新进展
李峥,刘旭
摘要(Abstract):
<正>心房颤动(房颤)是最常见的心律失常之一,其发病率随年龄增长逐年升高,由于房颤能导致血液动力学的紊乱,容易在左房形成血栓,以致患者发生血栓栓塞事件。据统计,房颤患者的卒中发生率是正常人群的5倍。在我国,一项回顾性研究显示,中国人心房颤动相关卒中的发生率为
关键词(KeyWords):
基金项目(Foundation):
作者(Author): 李峥,刘旭
参考文献(References):
- [1]Wen-Hang QI,Society of Cardiology,Chinese Medical Association.Retrospective investigation of hospitalized patients with atrial fibrillation in China's mainland.Int J Cardiol,2005,105:283-287.
- [2]Hart RG,Pearce LA,Aguilar MI.Meta-analysis:antithrombotic therapy to prevent stroke in patients who have nonvalvular atrial fibrillation.Ann Intern Med,2007,146:857-867.
- [3]Piccini JP,Hernandez AF,Zhao X,et al.Quality of care for atrial fibrillation among patients hospitalized for heart failure.J Am Coll Cardiol,2009,54:1280-1289.
- [4]Bates SM,Weitz JI.The status of new anticoagulants.Br J Haematol,2006,134:3-19.
- [5]Wienen W,Stassen JM,Priepke H,et al.In-vitro profile and ex-vivo anticoagulant activity of the direct thrombin inhibitor dabigatran and its orally active prodrug,dabigatran etexilate.Thromb Haemost,2007,98:155-162.
- [6]Stangier J,Rathgen K,St-hle H,et al.The pharmacokinetics,pharmacodynamics and tolerability of dabigatran etexilate,a new oral direct thrombin inhibitor,in healthy male subjects.Br J Clin Pharmacol,2007,64:292-303.
- [7]Stangier J.Clinical pharmacokinetics and pharmacodynamics of the oral direct thrombin inhibitor dabigatran etexilate.Clin Pharmacokinet,2008,47:285-295.
- [8]Sanford M,Plosker GL.Dabigatran etexilate.Drugs,2008,68:1699-1709.
- [9]Eriksson BI,Dahl OE,Büller HR,et al.A new oral direct thrombin inhibitor,dabigatran etexilate,compared with enoxaparin for prevention of thromboembolic events following total hip or knee replacement:the BISTROⅡrandomized trial.J Thromb Haemost,2005;3:103-111.
- [10]Eriksson BI,Dahl OE,Rosencher N,et al.Oral dabigatran etexilate vs.subcutaneous enoxaparin for the prevention of venous thromboembolism after total knee replacement:the Re-modelrandomized trial.J Thromb Haemost,2007,5:2178-2185.
- [11]Eriksson BI,Dahl OE,Rosencher N,et al.Dabigatran etexilate versus enoxaparin for prevention of venous thromboembolism after total hip replacement:a randomized,double-blind,non-inferiority trial.Lancet,2007,370:949-956.
- [12]Ezekowitz MD,Reilly PA,Nehmiz G,et al.Dabigatran with or without concomitant aspirin compared with warfarin alone in patients with nonvalvular atrial fibrillation(PETRO Study).Am J Cardiol,2007,100:1419-1426.
- [13]Connolly SJ,Ezekowitz MD,Yusuf S,et al.Dabigatran versus warfarin in patients with atrial fibrillation.N Engl J Med,2009,361:1139-1151.
- [14]Veyrat-Follet C,Vivier N,Trellu M,et al.The pharmacokinetics of idraparinux,a long-acting indirect factorⅩa inhibitor:population pharmacokinetic analysis from phaseⅢclinical trials.J Thromb Haemost,2009,7:559-565.
- [15]Amadeus Investigators,Bousser MG,Bouthier J,et al.Comparison of idraparinux with Vitamin K antagonists for prevention of thromboembolism in patients with atrial fibrillation:a randomized,open label,non-inferiority trial.Lancet,2008,371:315-321.
- [16]Abe K,Siu G,Edwards S,et al.Animal models of thrombosis help predict the human therapeutic concentration of PRT54021,a potent oral factorⅩa inhibitor.Blood,2006,108:A901.
- [17]Exzekowitz M,Connolly S,Diaz R,et al.A Phase2,Randomized,Parallel Group,Dose-Finding,Multicenter,Multinational Study of the Safety,Tolerability and Pilot Efficacy of Three Blinded Doses of the Oral FactorⅩa Inhibitor Betrixaban Compared with Open-Label Dose-Adjusted Warfarin in Patients with Nonvalvular Atrial Fibrillation(EXPLORE-Ⅹa).American College of Cardiology59th Annual Scientific Session:Atlanta,GA,2010.
- [18]Kubitza D,Becka M,Wensing G,et al.Safety,pharmacodynamics,and pharmacokinetics of BAY59-7939:an oral,direct factorⅩa inhibitor-after multiple dosing in healthy male subjects.Eur J Clin Pharmacol,2005,61:873-880.
- [19]Piccini JP,Patel MR,Mahaffey KW,et al.Rivaroxaban,an oral direct factorⅩa inhibitor.Expert Opin Investig Drugs,2008,17:925-937.
- [20]Kubitza D,Mueck W,Becka M.Randomized,double-blind,crossover study to investigate the effect of rivaroxaban on QT-interval prolongation.Drug Saf,2008,31:67-77.
- [21]Agnelli G,Gallus A,Goldhaber SZ,et al.Treatment of proximal deep-vein thrombosis with the oral direct factorⅩa inhibitor rivaroxaban(BAY59-7939):the ODIXa-DVT(Oral Direct FactorⅩa Inhibitor BAY59-7939in Patients with Acute Symptomatic Deep-Vein Thrombosis)study.Circulation,2007,116:180-187.
- [22]Mega,JL,Braunwald E,Mohanavelu S,et al.Rivaroxaban versus placebo in patients with acute coronary syndromes(ATLAS ACS-TIMI46):a randomised,double-blind,phaseⅡtrial.Lancet,2009,374:29-38.
- [23]ROCKETAF Study Investigators.Rivaroxaban-once daily,oral,direct factorⅩa inhibition compared with vitamin K antagonism for prevention of stroke and Embolism Trial in Atrial Fibrillation:rationale and design of the ROCKET AF study.Am Heart J,2010,159:340-347.e1.