李绍生,邓捷,赵昕,史雅娜,王效增

• 1:沈阳军区总医院心血管内科
• 2:解放军230医院心血管内科

摘要(Abstract)：

目的探讨对中国冠心病人群测定冠状动脉血流储备分数(fractional fl ow reserve,FFR)中冠状动脉内弹丸式注射腺苷(adenosine,AD)的合适剂量。方法以32例冠心病患者的40支中度狭窄病变冠状动脉血管为研究对象,将60μg(A1)、80μg(A2)、100μg(A3)和120μg(A4)的AD随机以弹丸式注入靶血管进行FFR测定。记录FFR值、注射后不良反应、血流动力学改变及是否存在房室传导阻滞。结果注射后FFR值由基础的0.891±0.044明显下降了8.99%(A1)、11.24%(A2)、13.48%(A3)和13.48%(A4)(均P<0.001)。A3和A4则比A1(t=6.331、6.343,均P<0.001)、A2(t=2.974、3.058,P=0.005、0.004)更低。各剂量组分别有12支(30.0%)、13支(32.5%)、14支(35.0%)和14支(35.0%)靶病变的FFR<0.75。13例(40.6%)患者出现了AD相关不良反应。结论在我国冠心病人群冠状动脉内弹丸式注射AD与FFR测定值具有明显的剂量依赖性,合适的剂量是100μg。

关键词(KeyWords)： 腺苷;血流储备分数;冠状动脉粥样硬化性心脏病;冠状动脉造影

Abstract:

Keywords:

基金项目(Foundation): 中国医师协会阳光心血管研究基金项目课题(SCRFCMDA201219)

作者(Author): 李绍生,邓捷,赵昕,史雅娜,王效增

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