肺静脉在犬迷走神经介导性心房颤动维持中作用的研究Role of pulmonary veins in sustained vagotonic atrial fibrillation in canines
王玉堂,国建萍,单兆亮,周俊彦,苑洪涛,王卫华,时向民
摘要(Abstract):
目的研究单纯肺静脉隔离在阵发性迷走神经介导性心房颤动(迷走性房颤)中的作用。方法杂种犬10只,分别刺激颈部迷走神经干诱发出持续性房颤。在心外膜进行肺静脉隔离,分别比较消融前后左、右心房的有效不应期(AERP),房颤的诱发率、持续时间和房颤波周长(AFCL)的变化。结果肺静脉隔离后,左、右心房AERP较消融前明显延长,AFCL明显延长,左、右心房AERP的差异明显缩短,房颤仍持续直至停止迷走神经刺激。结论肺静脉在迷走性房颤的维持上不起决定性的作用。
关键词(KeyWords): 心房颤动;肺静脉;迷走神经;犬
基金项目(Foundation):
作者(Author): 王玉堂,国建萍,单兆亮,周俊彦,苑洪涛,王卫华,时向民
参考文献(References):
- [1]Nattel S,Bourne G,Talajic M.Insights into mechanisms ofantiarrhythmic drugs action from experimental models of atrialfibrillation.J Cardiovasc Electrophysiol,1997,8:469-480.
- [2]Chen YJ,Chen SA,Tai CT,et al.Role of atrial electrophysiologyand autonomic nervous system in patients with supraventriculartachycardia and paroxysmal atrial fibrillation.J Am Coll Cardiol,1998,32:732-738.
- [3]Scherlag BJ,Yamanashi WS,Schauerte P,et al.Endovascularstimulation within the left pulmonary artery to induce slowing of heartrate and paroxysmal atrial fibrillation.Cardiovascular Research,2002,54:470-475.
- [4]Oral H,Chugh A,Scharf C,et al.Pulmonary vein isolation forvagotonic,adrenergic,and random episodes of paroxysmal atrialfibrillation.J Cardiovasc Electrophysiol,2004,15:402-405.
- [5]单兆亮,王玉堂,时向民,等.持续性心房颤动山羊模型的制作.心脏杂志,2005,17:520-522.
- [6]单兆亮,王玉堂,时向民,等.心房可兴奋间期对山羊心房颤动稳定性的影响.中华心血管病杂志,2005,33:992-994.
- [7]Coumel P,Attuel P,Lavallee JP,et al.Syndrome d arythmicauriculaire d origine vagale.Arch Mal Coeur,1978:71:645-656.
- [8]Haissaguerre M,Jais P,Shah DC,et al.Spontaneous initiation ofatrial fibrillation by ectopic beats originating in the pulmonary veins.N Engl J Med,1998,339:659-666.
- [9]Cha TJ,Ehrlich JR,Zhang L,et al.Atrial tachycardia remodelingof pulmonary vein cardiomyocytes:comparison with left atrium andpotential relation to arrhythmogenesis.Circulation,2005,111:728-735.
- [10]Chiou CW,Eble JN,Zipes DP,et al.Efferent vagal innervation ofthe canine atria and sinus and atrioventricular nodes.Circulation,1997,95:2573-2584.