华倚虹

• 1:中国医学科学院 北京协和医学院 国家心血管病中心 阜外心血管病医院冠心病中心

摘要(Abstract)：

<正>1血小板减少症的定义、发生率及鉴别诊断的重要意义替罗非班是一种血小板糖蛋白Ⅱb/Ⅲa抑制剂,能阻断纤维蛋白原与血小板表面血小板糖蛋白Ⅱb/Ⅲa受体的结合,从而阻断血小板激活和聚集,在急性冠状动脉综合征以及经皮冠状动脉介入治疗领域都有较多的应用。然而,来自临床试验的结果显示,使用替罗非班的患者有可能发生替罗非班相

关键词(KeyWords)： 血小板减少症;替罗非班;肝素

Abstract:

Keywords:

基金项目(Foundation):

作者(Author): 华倚虹

参考文献(References)：

• [1]Said SM,Hahn J,Schleyer E,et al.GlycoproteinⅡb/Ⅲa inhibitor-induced thrombocytopenia:diagnosis and treatment.Clin Res Cardiol,2007,96:61-69.
• [2]Abrams CS,Cines DB.Thrombocytopenia after treatment with platelet glycoproteinⅡb/Ⅲa inhibitors.Curr Hematol Rep,2004,3:143-147.
• [3]Huynh T,Piazza N,DiB attiste PM,et al.Analysis of bleeding complications associated with glycoproteinⅡb/Ⅲa receptors blockade in patients with high-risk acute coronary syndromes:insights from the PRISM-PLUS study.Int J Cardiol,2005,100:73-78.
• [4]Aster RH.Immune thrombocytopenia caused by glycoproteinⅡb/Ⅲa inhibitors.Chest,2005,127(2 Suppl):53S-59S.
• [5]Rizvi MA,Kojouri K,George JN.Drug-induced thrombocytopenia:an updated systematic review.Ann Intern Med,2001,134:346.
• [6]Sane DC,Damaraju LV,Topol EJ,et al.Occurrence and clinical significance of pseudothrombocytopenia during abciximab therapy.J Am Coll Cardiol,2000,36:75-83.
• [7]Cines DB,Tomaski A,Tannenbaum S.Immune endothelial-cell injury in heparin-associated thrombocytopenia.N Engl J Med,1987,316:581-589.
• [8]徐立,杨新春,王乐丰,等.急性心肌梗死急诊介入治疗联合应用替罗非班发生血小板减少症的临床分析——替罗非班可能的副作用.中国介入心脏病学杂志,2008,16:5-7.
• [9]鲁硕,王亦舒,侯凤霞.急性心肌梗死经皮冠状动脉介入治疗术后支架内血栓伴血小板减少二例.中国介入心脏病学杂志,2014,22:403-405.
• [10]Roy SK,Howard EW,Panza JA,et al.Clinical implications of thrombocytopenia among patients undergoing intra-aortic balloon pump counterpulsation in the coronary care unit.Clin Cardiol,2010,33:30-35.