前壁心肌梗死患者自体骨髓单个核细胞移植治疗的可行性研究The feasibility of autologous mononuclear bone marrow cells transplantation in patients with anterior myocardial infarction
刘健,王伟民,孙宁玲,张萍,刘开彦,汪素,王茜,臧越,杨松娜,王靖,陆道培,郭继鸿
摘要(Abstract)：
目的 评价经冠状动脉内注射自体骨髓单个核细胞治疗心肌梗死患者的可行性。方法 本项前瞻性、非随机、对照研究入选2 2例陈旧性前壁心肌梗死患者(其中1 4例患者为细胞治疗组,8例患者为常规治疗组)。两组患者均接受标准的介入治疗和药物治疗,细胞移植组的1 4例患者采用Over the Wire(OTW )球囊导管将自体骨髓单个核细胞缓慢注入前降支。结果 细胞移植组中1例患者因支架内急性血栓形成而死亡。其余1 3例和常规治疗组的8例患者术中及术后无心肌缺血及心律失常的发生。两组患者均于术后3个月和6个月随访,并行6分钟步行试验、超声心动图、心肌双核素和心脏核磁等检查。3个月的检查结果提示,细胞移植组左室射血分数[( 4 0 .1 2±5 .52 ) %vs( 50 . 37±7. 31 ) % ,P =0 . 0 0 0 1 ],与常规治疗组差异有统计学意义[( 50 .37±7 .31 ) %vs ( 4 4. 0 9±3 .50 ) % ,P =0 . 0 35]。结论 前壁心肌梗死患者经冠状动脉内行自体骨髓单个核细胞移植具有良好的可行性,可以显著改善左室收缩功能。
关键词(KeyWords)： 心肌梗死;单核细胞;骨髓移植
基金项目(Foundation):
作者(Author): 刘健,王伟民,孙宁玲,张萍,刘开彦,汪素,王茜,臧越,杨松娜,王靖,陆道培,郭继鸿
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