赵琳茹,李广平

• 1:天津市心血管病离子与分子机能重点实验室天津医科大学第二医院心脏科天津心脏病学研究所

摘要(Abstract)：

<正>急性心肌梗死(acute myocardial infarction,AMI)治疗的首要目标为实现心肌早期再灌注,而早期再灌注治疗主要体现在尽早开通梗死相关动脉(infarction related artery,IRA)。经皮冠状动脉介入治疗(percutaneous coronary intervention,PCI)已经成为冠心病治疗的重要手段,而直接经皮冠状动脉

关键词(KeyWords)： 经皮冠状动脉介入治疗;溶栓;急性心肌梗死

Abstract:

Keywords:

基金项目(Foundation):

作者(Author): 赵琳茹,李广平

参考文献(References)：

• [1]O'Gara PT,Kushner FG,Ascheim DD,et al.2013 ACCF/AHA guideline for the management of ST-elevation myocardial infarction:executive summary:a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines.J Am Coll Cardiol,2013,61(4):485-510.
• [2]Taylor J.2012 ESC Guidelines on acute myocardial infarction(STEMI).Eur Heart J,2012,33(20):2501-2502.
• [3]Levine GN,Bates ER1,Blankenship JC,et al.2015 ACC/AHA/SCAI Focused Update on Primary Percutaneous Coronary Intervention for Patients With ST-Elevation Myocardial Infarction:An Update of the 2011 ACCF/AHA/SCAI Guideline for Percutaneous Coronary Intervention and the 2013 ACCF/AHA Guideline for the Management of ST-Elevation Myocardial Infarction:A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines and the Society for Cardiovascular Angiography and Interventions.Circulation,2016,133(11):1135-1147.
• [4]中华医学会心血管病学分会,中华心血管病杂志编辑委员会.急性ST段抬高型心肌梗死诊断和治疗指南.中华心血管病杂志,2015,43(5):380-393.
• [5]丁嵩,何奔.急性ST段抬高心肌梗死介入治疗:关注心肌的有效再灌注.中国介入心脏病学杂志,2015,23(10):573-576.
• [6]Kristensen SD,Laut KG,Fajadet J,et al.Reperfusion therapy for ST elevation acute myocardial infarction 2010/2011:current status in 37 ESC countries.Eur Heart J,2014,35(29):1957-1970.
• [7]Al-Zakwani I,Zubaid M,Al-Riyami A,et al.Primary coronary intervention versus thrombolytic therapy in myocardial infarction patients in the Middle East.Int J Clin Pharm,2012,34(3):445-451.
• [8]Kunadian V,Gibson CM.Thrombolytics and myocardial infarction.Cardiovasc Ther,2012,30(2):e81-e88.
• [9]蒋立新.China PEACE研究的启示——我国迫切需要进行心肌梗死等重大疾病的医疗质量改善研究.中国循环杂志,2014,29(6):401-403.
• [10]Fletcher AP,Alkjaersig N,Smyrniotis FE,et al.The treatment of patients suffering from early myocardial infarction with massive and prolonged streptokinase therapy.Trans Assoc Am Physicians,1958,71:287-296.
• [11]Chazov EI,Matveeva LS,Mazaev AV,et al.Intracoronary administration of fibrinolysin in acute myocardial infarct.Ter Arkh,1976,48(4):8-19.
• [12]Rentrop KP,Blanke H,Karsch KR,et al.Acute myocardial infarction:intracoronary application of nitroglycerin and streptokinase.Clin Cardiol,1979,2(5):354-363.
• [13]Yusuf S,Collins R,Peto R,et al.Intravenous and intracoronary fibrinolytic therapy in acute myocardial infarction:overview of results on mortality,reinfarction and side-effects from 33randomized controlled trials.Eur Heart J,1985,6(7):556-585.
• [14]No authors listed.Effectiveness of intravenous thrombolytic treatment in acute myocardial infarction.Gruppo Italiano per lo Studio della Streptochinasi nell'Infarto Miocardico(GISSI).Lancet,1986,1(8478):397-402.
• [15]Longstaff C,Williams S,Thelwell C.Fibrin binding and the regulation of plasminogen activators during thrombolytic therapy.Cardiovasc Hematol Agents Med Chem,2008,6(3):212-223.
• [16]余巧燕,孙晋民.溶栓药物的研究进展.医学理论与实践,2009,22(1):30-33.
• [17]De Luca G,Suryapranata H,Ottervanger JP,et al.Time delay to treatment and mortality in primary angioplasty for acute myocardial infarction:every minute of delay counts.Circulation,2004,109(10):1223-1225.
• [18]Jacobs AK,Antman EM,Faxon DP,et al.Development of systems of care for ST-elevation myocardial infarction patients:executive summary.Circulation,2007,116(2):217-230.
• [19]Weaver WD,Simes RJ,Betriu A,et al.Comparison of primary coronary angioplasty and intravenous thrombolytic therapy for acute myocardial infarction:a quantitative review.JAMA,1997,278(23):2093-2098.
• [20]Topol EJ.Acute myocardial infarction:thrombolysis.Heart,2000,83(1):122-126.
• [21]Stephan W,Kolh P,Alfonso F,et al.2014 ESC/EACTS guidelines on myocardial revascularization.Rev Esp Cardiol(Engl Ed),2015,68(2):144.
• [22]Bjorklund E,Stenestrand U,Lindback J,et al.Pre-hospital thrombolysis delivered by paramedics is associated with reduced time delay and mortality in ambulance-transported real-life patients with ST-elevation myocardial infarction.Eur Heart J,2006,27(10):1146-1152.
• [23]Pinto DS,Frederick PD,Chakrabarti AK,et al.Benefit of transferring ST-segment-elevation myocardial infarction patients for percutaneous coronary intervention compared with administration of onsite fibrinolytic declines as delays increase.Circulation,2011,124(23):2512-2521.
• [24]Steg PG,Bonnefoy E,Chabaud S,et al.Impact of time to treatment on mortality after prehospital fibrinolysis or primary angioplasty:data from the CAPTIM randomized clinical trial.Circulation,2003,108(23):2851-2856.
• [25]GREAT Group.Feasibility,safety,and efficacy of domiciliary thrombolysis by general practitioners:Grampian region early anistreplase trial.BMJ,1992,305(6853):548-553.
• [26]Rawles J.GREAT:10 year survival of patients with suspected acute myocardial infarction in a randomised comparison of prehospital and hospital thrombolysis.Heart,2003,89(5):563-564.
• [27]Bonnefoy E,Lapostolle F,Leizorovicz A,et al.Primary angioplasty versus prehospital fibrinolysis in acute myocardial infarction:a randomised study.Lancet,2002,360(9336):825-829.
• [28]Armstrong PW,Gershlick AH,Van de Werf F.Fibrinolysis or primary PCI in myocardial infarction.N Engl J Med,2013,369(3):280-281.
• [29]Gilmour KM,Iversen L,Hannaford PC.Long-term survival benefits of thrombolysis:the Royal College of General Practitioners'myocardial infarction study.Fam Pract,2015,32(2):192-197.
• [30]Assessment of the Safety and Efficacy of a New Treatment Strategy with Percutaneous Coronary Intervention(ASSENT-4PCI)investigators.Primary versus tenecteplase-facilitated percutaneous coronary intervention in patients with ST-segment elevation acute myocardial infarction(ASSENT-4 PCI):randomised trial.Lancet,2006,367(9510):569-578.
• [31]Zalewski J,Bogaerts K,Desmet W,et al.Intraluminal thrombus in facilitated versus primary percutaneous coronary intervention:an angiographic substudy of the ASSENT-4 PCI(Assessment of the Safety and Efficacy of a New Treatment Strategy with Percutaneous Coronary Intervention)trial.J Am Coll Cardiol,2011,57(19):1867-1873.
• [32]So DY,Ha AC,Davies RF,et al.ST segment resolution in patients with tenecteplase-facilitated percutaneous coronary intervention versus tenecteplase alone:Insights from the Combined Angioplasty and Pharmacological Intervention versus Thrombolysis ALone in Acute Myocardial Infarction(CAPITAL AMI)trial.Can J Cardiol,2010,26(1):e7-12.
• [33]Itoh T,Fukami K,Suzuki T,et al.Comparison of long-term prognostic evaluation between pre-intervention thrombolysis and primary coronary intervention:a prospective randomized trial:five-year results of the IMPORTANT study.Circ J,2010,74(8):1625-1634.
• [34]Han YL,Liu JN,Jing QM,et al.The efficacy and safety of pharmacoinvasive therapy with prourokinase for acute ST-segment elevation myocardial infarction patients with expected long percutaneous coronary intervention-related delay.Cardiovasc Ther,2013,31(5):285-290.
• [35]Cantor WJ,Fitchett D,Borgundvaag B,et al.Routine early angioplasty after fibrinolysis for acute myocardial infarction.N Engl J Med,2009,360(26):2705-2718.
• [36]Jager B,Farhan S,Kalla K,et al.One-year mortality in patients with acute ST-elevation myocardial infarction in the Vienna STEMI registry.Wien Klin Wochenschr,2015,127(13-14):535-542.
• [37]Arso IA,Setianto BY,Taufiq N,et al.In-hospital major cardiovascular events between STEMI receiving thrombolysis therapy and primary PCI.Acta Med Indones,2014,46(2):124-130.
• [38]Danchin N,Blanchard D,Steg PG,et al.Impact of prehospital thrombolysis for acute myocardial infarction on 1-year outcome:results from the French Nationwide USIC 2000 Registry.Circulation,2004,110(14):1909-1915.
• [39]陆建辉,洪小苏,徐卫亭.急性心肌梗死介入治疗与溶栓治疗的疗效比较.苏州大学学报(医学版),2006,26(3):417-420.