冠心病合并2型糖尿病患者冠状动脉造影分析Clinical analysis of coronary angiography in coronary heart disease with type 2 diabetes mellitus
宫建丽,张秀洲,李文华,孔香云,张祖煌,唐元升,朱兴雷
摘要(Abstract):
目的探讨冠心病(CHD)合并2型糖尿病患者的冠状动脉造影特点。方法从冠状动脉造影病例中选取454例(其中冠心病合并2型糖尿病203例,单纯冠心病251例)进行血生化和血管造影资料对比分析。结果与单纯冠心病组比较,冠心病合并2型糖尿病组甘油三酯(TG)水平高,载脂蛋白A(apoA)水平低;四支病变比例高(17.3%比9.5%,P<0.05),单支病变比例低(16.3%比26.3%,P<0.05),且血管狭窄程度重(狭窄程度≥75%的比例为66%比61.3%,P<0.05)。结论合并2型糖尿病与不合并2型糖尿病的冠心病患者的冠状动脉造影表现的差异有统计学意义,前者冠状动脉病变更加广泛和严重。
关键词(KeyWords): 冠状动脉疾病;糖尿病,非胰岛素依赖型;冠状血管造影术
基金项目(Foundation): 山东省科技发展计划(2003—35)号
作者(Author): 宫建丽,张秀洲,李文华,孔香云,张祖煌,唐元升,朱兴雷
参考文献(References):
- [1]赵晓娟.2型糖尿病的降脂治疗策略与评价.中国实用内科杂志,2004,24:136-138.
- [2]Cleeman JI.Executive summary of the third report of the NationalCholesterol Education Program(NCEP)expert panel on detection,valuation,and treatment of high blood cholesterol in adults(AdultTreatment PanelⅢ).JAMA,2001,285:2486-2497.
- [3]陈明,高炜,朱国英,等.冠心病合并非胰岛素依赖型糖尿病患者冠脉造影特点.中华内科杂志,1999,38:27-29.
- [4]宫建丽,李文华,孔香云,等.血脂及增龄对冠心病合并2型糖尿患者冠状动脉造影特点的影响.中国介入心脏病学杂志,2005,13:371-374.
- [5]Eugene AC,Bernard RC,Sandra AF,et al.Diabetes with coronarydisease have a prevalence of asymptomatic ischemia during exercisetreadmill testing and ambulatory ischemia monitoring similar to that ofnondiabetic patients.Circulation,1996,93:2091-2098.
- [6]Van BE,Bauters C,Hubert E,et al.Restenosis rates in diabeticpatients:a comparision of coronary stenting and balloon angioplasty innative coronary vessels.Circulation,1997,96:1374.
- [7]Cariou B,Bonnevie L,Mayandon H,et al.Angiographic character-istics of coronary artery disease in diabetic patients compared withmatched nondiabetic patients.Diahetes Nutr Metab,2000,13:134-141.
- [8]Solymoss BC,Bourassa MG,Campeau L,et,al.Incidence,coronaryrisk profile and angiographic characteristics of prediabetic and diabet-ic patients in a population with ischemic heart disease.Can J Cardi-ol,2003,19:1155-1160.
- [9]Falcone C,Nespoli L,Geroldi D,et al.Dilent myocardial ischemiain diabetic and nondiabetic patients with coronary artery disease.Int JCardiol,2003,90:219-227.
- [10]Blankenhorn DH,Azen SP,Kramsch DM,et al。Coronary angiograph-ic changes with lovastain therapy.The Monitered Atheroslerosis Re-gression Study(MARS).Ann Intern Med,1993,19:969-976.
- [11]Grundy SM.Hypertriglyceridemia,Atherogenic dyslipidemia,andthemetabolic syndrom.Am J Cardiol,1998,81:18B-25B.