严红,毕君富,张斌,董太明,乌汉东,于汇民,靳立军

• 1:广东省心血管病研究所 广东省人民医院心内科 广东省医学科学院
• 2:广东省湛江农垦第二医院心内科

摘要(Abstract)：

目的探讨年龄在50岁及以下的女性冠心病患者的危险因素、临床及冠状动脉造影特点。方法选取经临床及冠状动脉造影确诊的50岁及以下女性冠心病住院患者共173例作为疾病组,同期收治的50岁及以下冠状动脉造影正常的非冠心病住院患者共494例作为对照组,对比分析两组间冠心病危险因素、临床及冠状动脉造影特点。结果疾病组中糖尿病患者、冠心病家族史患者、血脂异常患者及高血压患者比例均明显高于对照组(P<0.05),且疾病组患者舒张压、空腹血糖值也明显高于对照组(P<0.05),而体重、收缩压、停经年龄等则与对照组差异无统计学意义(P>0.05);疾病组血清总胆固醇、三酰甘油值明显高于对照组(P<0.05),而高密度脂蛋白、载脂蛋白A值则明显低于对照组(P<0.05);尿蛋白阳性患者比例,疾病组明显高于对照组(P<0.05);而血清尿酸、肌酸酐(肌酐)两组间比较差异无统计学意义;疾病组中,单支冠状动脉病变患者占53.8%;多支病变患者占31.2%;冠状动脉轻度狭窄或正常患者占15.0%。受累的冠状动脉以左前降支及其分支最多,其次为右冠状动脉及其分支。结论 50岁及以下女性冠心病患者的主要危险因素为糖尿病、冠心病阳性家族史、血脂异常、高血压(尤其是舒张压高)及尿蛋白阳性。单纯停经而没有伴随冠心病其他危险因素,可能不会导致冠心病发病率的增加。这些患者冠状动脉病变以单支病变最多见,相当部分患者冠状动脉仅轻度异常甚或未见异常。

关键词(KeyWords)： 50岁;女性;冠心病;危险因素;冠状动脉造影

Abstract:

Keywords:

基金项目(Foundation):

作者(Author): 严红,毕君富,张斌,董太明,乌汉东,于汇民,靳立军

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