卢亚辉,侯昌,刘健

• 1:北京大学人民医院心血管内科急性心肌梗死早期预警和干预北京市重点实验室

摘要(Abstract)：

冠状动脉腔内影像学因其更高的分辨率和组织区分度而被广泛应用到冠状动脉诊疗中。2020年有许多的临床研究进一步证明了腔内影像技术在冠心病诊疗中的作用。CLIMA、COMBINE等前瞻性研究进一步明确了光学相干断层成像(OCT)在识别易损斑块中的优势,及易损斑块对冠心病患者预后的影响。而EROSION研究、COMPLETE研究等也说明OCT对急性冠状动脉综合征患者进行危险分层及对非罪犯病变干预的指导意义。前瞻性研究及真实世界研究进一步证实了腔内影像学在钙化病变、左主干病变、慢性完全闭塞性病变等复杂冠状动脉病变诊疗中的作用。随着相关研究的不断丰富,腔内影像学会越来越广泛地应用于指导冠状动脉病变的介入治疗中。

关键词(KeyWords)： 血管内超声;光学相干断层成像;腔内影像学;经皮冠状动脉介入治疗;冠心病

Abstract:

Keywords:

基金项目(Foundation): 国家自然科学基金重点项目（11832003）;国家自然科学基金面上项目（81970294）

作者(Author): 卢亚辉,侯昌,刘健

参考文献(References)：

• [1] Neumann FJ, Sousa-Uva M, Ahlsson A,et al. 2018 ESC/EACTS Guidelines on myocardial revascularization. Eur Heart J, 2019, 40(2):87-165.
• [2] R?ber L, Mintz GS, Koskinas KC, et al. Clinical use of intracoronary imaging. Part 1:guidance and optimization of coronary interventions.An expert consensus document of the European Association of Percutaneous Cardiovascular Interventions. Eur Heart J, 2018, 39(35):3281-3300.
• [3] Johnson TW, R?ber L, di Mario C, et al. Clinical use of intracoronary imaging. Part 2:acute coronary syndromes, ambiguous coronary angiography findings, and guiding interventional decision-making:an expert consensus document of the European Association of Percutaneous Cardiovascular Interventions. Eur Heart J, 2019, 40(31):2566-2584.
• [4] Araki M, Soeda T, Kim HO, et al. Spatial distribution of vulnerable plaques:comprehensive in vivo coronary plaque mapping. JACC Cardiovasc Imaging, 2020, 13(9):1989-1999.
• [5] Prati F, Romagnoli E, Gatto L, et al. Relationship between coronary plaque morphology of the left anterior descending artery and 12months clinical outcome:the CLIMA study. Eur Heart J, 2020, 41(3):383-391.
• [6] Kennedy MW, Fabris E, Ijsselmuiden AJ, et al. Combined optical coherence tomography morphologic and fractional flow reserve hemodynamic assessment of non-culprit lesions to better predict adverse event outcomes in diabetes mellitus patients:COMBINE(OCT–FFR)prospective study. Rationale and design. Cardiovasc Diabetol, 2016, 15:144.
• [7] Nakazawa G, Finn AV, Joner M et al. Delayed arterial healing and increased late stent thrombosis at culprit sites after drug-eluting stent placement for acute myocardial infarction patients:an autopsy study. Circulation, 2008, 118(11):1138-1145.
• [8] Yamamoto MH, Maehara A, Stone GW, et al. 2-Year outcomes after stenting of lipid-rich and nonrich coronary plaques. J Am Coll Cardiol, 2020, 75(12):1371-1382.
• [9] Shishikura D, Kataoka Y, Di Giovanni G, et al. Progression of ultrasound plaque attenuation and low echogenicity associates with major adverse cardiovascular events. Eur Heart J, 2020, 41(31):2965-2973.
• [10] Vallabhajosyula S, El Hajj SC, Bell MR, et al. Intravascular ultrasound, optical coherence tomography, and fractional flow reserve use in acute myocardial infarction. Catheter Cardiovasc Interv, 2020, 96(1):E59-E66.
• [11] Kim N, Lee JH, Jang SY, et al. Intravascular modality-guided versus angiography-guided percutaneous coronary intervention in acute myocardial infarction. Catheter Cardiovasc Interv, 2020, 95(4):696-703.
• [12] Jia H, Dai J, Hou J, et al. Effective anti-thrombotic therapy without stenting:intravascular optical coherence tomography-based management in plaque erosion(the EROSION study). Eur Heart J,2017, 38(11):792-800.
• [13] He L, Qin Y, Xu Y, et al. Predictors of non-stenting strategy for acute coronary syndrome caused by plaque erosion:4-year outcomes of the EROSION study. EuroIntervention,2021,17(6):497-505.
• [14] Montone RA, Niccoli G, Crea F, et al. Management of non-culprit coronary plaques in patients with acute coronary syndrome. Eur Heart J, 2020, 41(37):3579-3586.
• [15] Mehta SR, Wood DA, Storey RF, et al. COMPLETE Trial Steering Committee and Investigators. Complete revascularization with multivessel PCI for myocardial infarction. N Engl J Med, 2019,381:1411-1421.
• [16] Pinilla-Echeverri N, Mehta SR, Wang J, et al. Nonculprit lesion plaque morphology in patients with ST-segment-elevation myocardial infarction:results from the COMPLETE trial optical coherence tomography substudys. Circ Cardiovasc Interv, 2020,13(7):e008768.
• [17] Stone GW, Maehara A, Ali ZA, et al. Percutaneous coronary intervention for vulnerable coronary atherosclerotic plaque. J Am Coll Cardiol, 2020,76(20):2289-2301.
• [18] Dai J, Fang C, Zhang S, et al. Frequency, predictors, distribution,and morphological characteristics of layered culprit and nonculprit plaques of patients with acute myocardial infarction:in vivo 3-vessel optical coherence tomography study. Circ Cardiovasc Interv, 2020,13(10):e009125.
• [19] Russo M, Kim HO, Kurihara O, et al. Characteristics of non-culprit plaques in acute coronary syndrome patients with layered culprit plaque. Eur Heart J Cardiovasc Imaging, 2020, 21(12):1421-1430.
• [20] Gerbaud E, Arabucki F, Nivet H, et al. OCT and CMR for the diagnosis of patients presenting with minoca and suspected epicardial causes. JACC Cardiovasc Imaging, 2020, 13(12):2619-2631.
• [21] Reynolds HR, Maehara A, Kwong RY, et al. Coronary optical coherence tomography and cardiac magnetic resonance imaging to determine underlying causes of MINOCA in women.Circulation, 2021,143(7):624-640.
• [22] Burzotta F, Leone AM, Aurigemma C, et al. Fractional flow reserve or optical coherence tomography to guide management of angiographically intermediate coronary stenosis:a single-center trial.JACC Cardiovasc Interv, 2020, 13(1):49-58.
• [23] Khalifa AKM, Kubo T, Ino Y, et al. Optical coherence tomography comparison of percutaneous coronary intervention among plaque rupture, erosion, and calcified nodule in acute myocardial infarction. Circ J, 2020, 84(6):911-916.
• [24] Nakajima A, Araki M, Kurihara O, et al. Comparison of poststent optical coherence tomography findings among three subtypes of calcified culprit plaques in patients with acute coronary syndrome.Catheter Cardiovasc Interv, 2021,97(4):634-645.
• [25] Kobayashi N, Ito Y, Yamawaki M, et al. Optical coherence tomography-guided versus intravascular ultrasound-guided rotational atherectomy in patients with calcified coronary lesions.Euro Intervention, 2020, 16(4):e313-e321.
• [26] Kinnaird T, Johnson T, Anderson R, et al. Intravascular imaging and 12-month mortality after unprotected left main stem pci:an analysis from the British Cardiovascular Intervention Society Database. JACC Cardiovasc Interv, 2020, 13(3):346-357.
• [27] Amabile N, RangéG, Souteyrand G, et al. Optical coherence tomography to guide percutaneous coronary intervention of the left main coronary artery:the LEMON study. EuroIntervention,2021,17(2):e124-e131.
• [28] Mentias A, Sarrazin MV, Saad M, et al. Long-term outcomes of coronary stenting with and without use of intravascular ultrasound.JACC Cardiovasc Interv, 2020, 13(16):1880-1890.
• [29] Hong SJ, Mintz GS, Ahn CM,et al. Effect of intravascular ultrasound-guided drug-eluting stent implantation:5-year follow-up of the IVUS-XPL randomized trial. JACC Cardiovasc Interv, 2020,13(1):62-71.
• [30] Lee SY, Kang DY, Hong SJ, et al. Optical coherence tomography for coronary bioresorbable vascular scaffold implantation:a randomized controlled trial. Circ Cardiovasc Interv, 2020, 13(1):e008383.
• [31] Katsura A, Minami Y, Kato A, et al. Novel volumetric analysis for stent expansion after drug-eluting stent implantation:an optical coherence tomography study. Catheter Cardiovasc Interv, 2020, 96(5):E501-E507.