大鼠心脏损伤模型上缺血预处理保护作用的研究Protective effect of iscbemic preconditioning on pre-injured heart in rats
武旭东,徐成斌,陈红,刘秀华,庞永政,唐朝枢
摘要(Abstract)：
在大鼠异丙基肾上腺素(isoprenaline,ISO)损伤模型上,观察缺血预处理(ischemic preconclitioning,IPC)对心脏的保护作用.与单纯缺血再灌注(ischemic reperfusion,I/R)损伤组比较,IPC能减轻I/R引起的冠脉流量降低,减少心肌组织蛋白、乳酸脱氢酶(LDH)及组织蛋白酶D(CD)的漏出,抑制MDA形成与Ca~(2+)聚集,其保护程度与IPC对正常心脏I/R损伤的保护程度相近.表明IPC对ISO损伤心脏仍有保护,提示IPC的心脏保护作用对已有缺血损伤的心脏仍然存在.
关键词(KeyWords)： 缺血预处理;异丙基肾上腺素;心脏;缺血再灌注损伤
基金项目(Foundation): 美国中华医学基金会基金资助课题
作者(Author): 武旭东,徐成斌,陈红,刘秀华,庞永政,唐朝枢
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