冠状动脉斑块形态与外周血肿瘤坏死因子、内皮素和白细胞介素-6的关系Analysis of the relationship between the coronary plaque morphology and tumor necrosis factor-alpha,endothelin and Interleukin-6 of peripheral circulation hematoplasma
张永春,黄陆力,娄婷叶,上官海娟,李红军,吕风华,张素荣
摘要(Abstract)：
目的通过观察冠心病患者冠状动脉粥样硬化斑块形态与血清肿瘤坏死因子(tumornecrosis factor-alpha,TNF-α)、内皮素(endothelin,ET)和白细胞介素6(Interleukin-6,IL-6)的关系,探讨斑块发生破裂的原因,进而为临床上防治不稳定斑块的破裂提供理论依据。方法测定经冠状动脉造影(Coronary angiography,CAG)确诊的230例“冠心病、心绞痛”患者以及230例CAG正常者的血清TNF-α,ET和IL-6水平,并比较其与不同冠状动脉斑块形态之间的关系。结果冠心病患者血清TNF-α,ET和IL-6水平明显高于正常对照组,2型斑块组血清上述指标水平显著高于1型3、型斑块组,且3型斑块组明显高于1型斑块组。结论冠状动脉粥样硬化的过程中有炎症反应参与,炎症因子TNF-α,ET和IL-6水平与冠状动脉病变斑块形态均是导致冠状动脉斑块破裂的重要因素。
关键词(KeyWords)： 冠状动脉疾病;肿瘤坏死因子;内皮素;白细胞介素6
基金项目(Foundation): 河南省科技厅资助项目(001170303)
作者(Author): 张永春,黄陆力,娄婷叶,上官海娟,李红军,吕风华,张素荣
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