盐酸替罗非班对急性心肌梗死急诊经皮冠状动脉介入治疗中TIMI血流影响的临床研究Effect of tirofiban on TIMI flow in patients with STEMI during primary PCI
唐强,霍勇,陈明,李建平,洪涛,郭来敬,王智,张树和,曲华清
摘要(Abstract)：
目的分析Ⅱb/Ⅲa受体拮抗剂盐酸替罗非班对ST段抬高急性心肌梗死(STEMI)患者急诊经皮冠状动脉介入治疗(PCI)治疗中TIMI血流的影响。方法选择急诊入院STEMI患者48名,分为试验组(盐酸替罗非班+PCI)27例和对照组(直接PCI)21例。收集所有病例的临床和冠状动脉造影资料,观察PCI术前、术后TIMI血流情况。结果试验组于术前应用盐酸替罗非班使PCI前梗死相关血管TIMI血流分级提高,试验组达1级血流者比例高于对照组(37%比9.5%,P<0.05);对照组完全闭塞者比例明显高于试验组(38.1%比7.4%,P<0.01);两组患者PCI术后TIMI3级血流比例差异无统计学意义,TIMI2级血流比例试验组低于对照组。结论Ⅱb/Ⅲa受体拮抗剂盐酸替罗非班可改善STEMI患者梗死相关血管的TIMI血流。
关键词(KeyWords)： 盐酸替罗非班;心肌梗死;血管成形术,经腔,经皮冠状动脉
基金项目(Foundation):
作者(Author): 唐强,霍勇,陈明,李建平,洪涛,郭来敬,王智,张树和,曲华清
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