陈洪江，朱国英，唐朝枢

• 1:北京医科大学第一临床医学院内心科，徐州医学院附属医院心内科

摘要(Abstract)：

内皮源性舒张因子及在再狭窄发生中的作用及生物学特性陈洪江，朱国英，唐朝枢一、ＥＤＲＦ的发现乙酰胆碱（Ａｃｈ）在体内可引起血管明显扩张，并产生低血压，而对离休血管条的作用结果却不一致，有时呈舒张反应，有时却呈轻微的收缩反应。直到１９８０年，Ｆｕｒｃｈｇ...

关键词(KeyWords)：

Abstract:

Keywords:

基金项目(Foundation):

作者(Author): 陈洪江，朱国英，唐朝枢

参考文献(References)：

• 1FurchgottRF，ZawadzkiJV．Theobligatoryroleofendothelialcellintherelationandarterialsmoothmusclebyacetycholine．Nature1980；288（7589）：373－376．2CherryPG，FurchgottRF，ZawadzkiJV，etal．Roleofendothelialcellsintherelaxationofisolatedarterybybradykinin．ProcNatlAcadSciUSA1982；72：2106－2110．3FurchgottRP．RoleofendotheliuminresponseofvascularsmoothmuscleCirRes1983；53：557－573．4FurchgottRF，KhanMT．Similartiesofbehaviourofnitricoxide（NO）andendothelium－derivedrelaxingfactorinaperfusioncascadebioassaySystem（abstr）．FedProc1987；46：385．5IgnarroLJ，ByrnsRE，BugaGM，etal．Endothlium－derivedrelaxingfactorfrompulmonaryarteryandveinpossessespharmacologicalandchemicalpropertiesthatareidenticaltothosefornitricoxideradical．CirRes1987；61：866．6PalmerRMJ，FerrigeAG，MoncadaS．Nitricoxidereleaseaccountsforthebiologicalactivityofendothelium－derivedrelaxingfactor．Nature1987；327：524－526．7HatchinsonPJA，PalmerRMJ，MoncadaS．Comparativepharmacologyofendothalium－derivedrelaxingfactorandnitricoxideinvascularstrips．EurJPharmueol1987；14l：445－1．8IgnarroLJ．Endothelium－derivednitricoxide：actionsandproperties．FASEBJ1989；3：31－36．9HoefferU，FeletouM，FlavahanNA，etal．Caninearteriesreleasetwodifferentendothelium－drivedrelaxingfactor．AmJPhysiol1989；257：H330－H333．10GrendyrgSS，WilcoxDE，RubanyiGM．Endothelium－derivedrelaxingfactorreleasedfromcaninefemorlarterybyacetycholinecannotbeidentifiedasfreenitricoxidebyelectronparamagneticresonancespectroscopy．CirRes1990；67：1446－2．11IgnarroLJ．Biologicalactionsandpropertiesofendothelium－derivedrelaxingfactorformedandreleasedfromarteriesandveins．CirRes1989；65：1．12MoncadsS，PalmerRMJ，HiggsEA．．BiosynthesisofnitricoxidefromL－Arginine：Apathwayfortheregulationofcellfunctionandcommunication．BiochemPharmacol1989；38：1709－5．13PearsonPJ．ProtaminereleaseEDRFfromartteries：Mechanismofhypotensionfollowinginfusion．JAmCollCardiol1991；17（2SupplA）：143A．14JohnsRA．Endothelium－derivedrelaxingfactor：Basicreviewandclinicalimplication．JournalofCardiothovacicandVascularAnesthesial1991：5：69－9．15LuscherTF，YanyZH，TschudiM，etal．Interactionbetweenendothelin－1andendothelium－derivedrelaxingfactorinhumanarteriesandveins．CirRes1990；66：1088－14．16SimonetS，BailliencourtJP，DescombesJJ，etal．HypoxiacausesanabnormalcontractileresponseintheatherosderotiCrabbitaorta．CirRes1993；72：616－630．17HoganJC，SmithJA，RichardsAC，etal．AterialnatriareticpeptideinhibitsEDRFreleasefrombloodvesselsoftherabbit．EurJPharmacol1989；65：129－134．18GoldME，BugaGM，WoodKS，etal．Antogonisticmodulatoryrolesofmagnesiumandcalciumonreleaseofendothelium－derivedrelaxingfactorandsmcothvasculartone．CirRes1990；66：355－366．19IgnarroLJ，BugaGM，ChaudhuriG．EDRFgenerationandreleasefromperfusedbovinepulmonaryarteryandvein．EurJPhartniacol1988；147；7988．20GrylewskiRJ，MoncadsS，PalmerRMJ．BioassayofPGI2andendothelium－derivedrelaxingfactor（EDRF）fromporcineaorticendothelialcells．BrJPharmacol1986；87：685－694．21ChristicMI，GriffithTM，LewisMJ．Acomparsionofbasedandagonist－stimulatedreleaseofendothelium－deriedrelaxingfactorfromdifferentvessels．BrJPharmacol1989；98：377－406．22BradtDS，SynderSH．Indentificationofnitricoxidesynthetase，acalcinm－requiringenzyme．ProNatlAcadSciUSA1990；87：682－685．23LansnianJB．Goingwiththeflow．Natare1988；331：481－482．24GriffithTM，EwardsDH，NewbyAC，etal．Preductionofendotbelium－derivedrelaxantfactorisdependentonoxidativephophyorylationandextracellularcalcium．CardiovascRes1989；20：7－12．25ChristicMI，LewisMJ．Vascularsmoothmusclesensitivitytoendothelim－derivedrelaxingfactorisdifferentindifferentarteries．BrJPharniacol1988；95：630－636．26BugaGM，GoldME，WoodKS．Endothelium－derivednitricoxiderelaxednon－vascularsmoothmuscle．EurJPharmacol，1989；161：61－72．27AlheidU，ErolichJC，ForstermannU．Endothelium－derivedrelaxingfactorfromculturedhumanendothelialcellsinhibitsaggregationofhumanplatelets．ThrombRes1987；47：561－571．28RadomskiMW，PalmerRMJ，MoncadsS．Endogenousnitricoxideinhibitshumanplateletadhesiontovascularendothelium．Lancet1987；8567：1057－1058．