刘凯园,徐吉喆,白明,王强,姚利和

• 1:兰州大学第一医院(第一临床医学院)
• 2:兰州大学第一医院心血管内科
• 3:兰州大学第一医院神经内科

摘要(Abstract)：

卵圆孔未闭与偏头痛存在显著共病现象，但其因果关系及经导管封堵术的疗效仍存争议。本文系统综述了卵圆孔未闭相关偏头痛的潜在生物标志物以及相关影像学评估，旨在为卵圆孔未闭相关偏头痛的临床诊疗提供理论依据。关键生物标志物包括血小板活化标志物、降钙素基因相关肽、同型半胱氨酸及血小板/淋巴细胞比值。影像学评估涵盖右向左分流程度（经胸超声心动图、经颅多普勒超声）、脑血管屏气指数、脑白质高信号特征、静息态功能磁共振成像脑功能网络改变、光学相干断层成像检测的原位血栓以及脑电图功率谱特征。研究表明，生物标志物与影像学技术的整合可提高疾病鉴别与治疗预测的准确性。当前研究仍面临因果关系不明确、检测标准化不足等挑战，未来需多学科协作，通过多模态指标建立个体化诊疗体系，为卵圆孔相关偏头痛的精准防治提供依据。

关键词(KeyWords)： 卵圆孔未闭;偏头痛;生物学标志物

Abstract:

Keywords:

基金项目(Foundation):

作者(Author): 刘凯园,徐吉喆,白明,王强,姚利和

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