THE PROTECTIVE EFFECT OF LIMB ISCHEMIC PRECONDITIONING ON IN VIVO HEART SUBJECTED TO ISCHEMIC REPERFUSIONTHE PROTECTIVE EFFECT OF LIMB ISCHEMIC PRECONDITIONING ON IN VIVO HEART SUBJECTED TO ISCHEMIC REPERFUSION
摘要(Abstract):
<正> In the model of m vivo rabbit heart subjected to ischemia/reperfusion(I/R),the effect of limb ischemic preconditioning(LIPC)on I/R injury ofrabbit heart was observed,in order to investigate the phenomenon oforgan crossed preconditioning.The esults found that both of limb andheart preconditioning limited myocardial infarct size(21.3±6.5 in limbIPC group and 19.5±6.3 in heart IPC group vs.36.7±7.2 in I/R group,p<0.05).reduced leakage of lactate dehydrogenase(LDH)frommyocardium(1895±164 in limb IPC group,1758±176 in heart IPCgroup vs.2792±189 U/L in I/R group,p<0.01).It is suggested tha limbIPC has a protective effect on limiting myocardial infarct size induced byI/R injury.The protective degress is similar to that of ischemicpreconditioning on heart
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