陆蕾,潘文志

• 1:上海理工大学东方泛血管器械创新学院
• 2:复旦大学附属中山医院心内科上海市心血管病研究所国家放射与治疗临床医学研究中心

摘要(Abstract)：

瓣膜性心脏病（VHD）是一种常见的结构性心脏病。对于重度VHD患者而言，人工瓣膜置换术是目前最有效的治疗方式。然而，现有的瓣膜假体存在一定的局限性：机械瓣需要终身抗凝治疗，而生物瓣耐久性有限，特别是年轻患者可能面临再次手术的风险。因此，如何提升人工瓣膜的性能并延长其使用寿命就成为了研究重点。近年来，材料科学的突破推动了高分子材料的快速发展，聚合物材料的应用为心脏瓣膜领域提供了更多选择。与生物瓣相比，聚合物瓣膜更薄、耐久性更长且血液相容性更好，具有广阔的应用前景。如今，以SIKELIA系统以及Tria外科瓣为代表的聚合物瓣膜正逐渐进入临床，其有效性和安全性得到初步验证。文章主要介绍了聚合物瓣膜材料、制备工艺以及国内外现状，以期为该领域的进一步研究和临床应用提供参考。

关键词(KeyWords)： 聚合物瓣膜;瓣膜置换;心脏瓣膜;耐久性;血流动力学

Abstract:

Keywords:

基金项目(Foundation):

作者(Author): 陆蕾,潘文志

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