李亚萍,郭丽君,张福春,李昭屏,高炜

• 1:北京大学第三医院心内科
• 2:北京大学第三医院心内科
• 3:北京大学第三医院心内科
• 4:北京大学第三医院心内科

摘要(Abstract)：

目的在急性心肌梗死(AMI)接受直接经皮冠状动脉介入(PCI)治疗的患者中,评价国产左旋卡尼汀(L-carnitine,L-CN)对缺血-再灌注损伤心肌的保护作用。方法连续入选发病12h内ST段抬高AMI接受PCI的患者42例,随机分L-CN治疗组22例和对照组20例。观察肌酸磷酸激酶同工酶(CK-MB)、心肌TMP分级、术中再灌注心律失常、低血压、心电图ST段回落>50%、左心室舒张末期内径(LVEDD)和射血分数(LVEF)的改变。结果与对照组比较,L-CN治疗组CK-MB峰值明显减低,达峰时间提前;术中出现再灌注心律失常、低血压的比例明显减少;术后1h ST段回落>50%的患者比例明显增多;术后3个月时LVEDD仅轻度增大,LVEF显著升高。结论左旋卡尼汀对AMI直接PCI治疗患者的心肌具有抑制再灌注损伤、缩小梗死面积、改善心室重构等多重保护作用。

关键词(KeyWords)： 左旋卡尼汀;心肌梗死;血管成形术,经皮,经腔冠状动脉

Abstract:

Keywords:

基金项目(Foundation):

作者(Author): 李亚萍,郭丽君,张福春,李昭屏,高炜

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