赵慧强,韩雅玲,王守力,陈晖,李虹伟,李东宝,张鹤萍,崔继福

• 1:首都医科大学附属北京友谊医院心血管病诊疗中心心内科
• 2:沈阳军区总医院全军心血管病研究所心内科
• 3:大连市中心医院心内科

摘要(Abstract)：

目的探讨采用铜丝缠绕型支架置入中国小型猪冠状动脉内的方法制作慢性完全闭塞病变(CTO)模型的可行性,建立一种新的CTO模型方法。方法 56头中国小型猪经股动脉穿刺,在前降支置入自制的铜丝缠绕型支架。分别在术前和术后1周、2周、4周、3个月、6个月时观察心电图、心脏超声和冠状动脉造影(CAG),然后处死取出心脏,取目标冠状动脉和梗死区域心肌,做病理学检查。结果 56头猪中共8头死亡,总的死亡率14.3%(8/56)。1周、2周时目标冠状动脉均为100%闭塞;4周、3月、6月时部分动物冠状动脉未完全闭塞(血栓机化再通),前向血流TIMI2～3级;完全闭塞的冠状动脉包括了绝对性闭塞(TIMI0级)和功能性闭塞(TIMI1级),并出现同侧的桥侧枝循环。以4周为CTO时间点,CTO模型的成功率为66.7%(28/42)。心肌病理学和心脏超声结果显示所有存活动物均发生了心肌梗死。冠状动脉病理学发现1、2周时闭塞病变处主要为血栓和炎症细胞浸润,4周、3个月、6个月时组血栓逐渐机化,发生纤维化,病变两端形成纤维帽,中间有微血管和孔道形成,与人体CTO病变极为相似。结论该CTO模型与人体CTO病变较为相似,而且有操作简单、创伤小、成本低、死亡率低、成功率高等诸多优点,可作为实验研究较好的动物模型。

关键词(KeyWords)： 冠状动脉闭塞;疾病模型,动物;猪

Abstract:

Keywords:

基金项目(Foundation): 辽宁省科技攻关计划(2007225004-8)

作者(Author): 赵慧强,韩雅玲,王守力,陈晖,李虹伟,李东宝,张鹤萍,崔继福

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