经皮腔内冠状动脉成形术后急性冠状动脉并发症患者血浆血管活性物质的变化Changes of circulating ET, A Ⅱ, CGRP after PTCA in the patients associated with acute coronary events
郑玉云,朱国英,霍勇,邢德智,洪涛,刘梅林,石湘芸,赵云涛
摘要(Abstract)：
33例行经皮腔内冠状动脉成形术的患者中,6例并发8例次急性冠状动脉事件.所有患者均于术前、术后15分钟、1小时、3小时和24小时从股动脉取血,采用放免法进行测定.结果,急性血管并发症组血浆血管紧张素II(AⅡ)于术前、术后、即刻和术后24小时分别比无并发症组增高27.8%(P<0.01)、59.7%(P<0.01)和38.1%(P<0.01).血浆内皮素(ET)在并发症组与无并发症组间比较差异无显著性.并发症组血浆降钙素基因相关肽(CGRP)于术后15分钟显著下降,较术前下降53.3%(P<0.05),术后1小时恢复;无并发症组血浆CGRP术后呈下降趋势,但与术前比较无统计学意义.并发症组术后AIII+ET/CGRP高峰出现早、恢复晚,术后即刻、15分钟分别比无并发症组增高了170%(P<0.01)和164%(P<0.01),提示急性血管并发症的发生可能与血浆AII、CGRP的变化有关.
关键词(KeyWords)： 经皮腔内冠脉成形术;血管紧张素Ⅰ;降钙素基因相关肽;内皮素
基金项目(Foundation):
作者(Author): 郑玉云,朱国英,霍勇,邢德智,洪涛,刘梅林,石湘芸,赵云涛
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