经皮导管肾交感神经消融在高血压治疗中的应用
孙党辉,李悦
摘要(Abstract)：
<正>高血压已成为全球性健康问题,其治疗策略主要基于生活方式改变和合理的药物治疗。尽管如此,许多高血压患者血压仍未能得到满意控制,经皮导管肾交感神经消融的出现为高血压患者提供了新的希望。一、肾交感神经与高血压
关键词(KeyWords)：
基金项目(Foundation):
作者(Author): 孙党辉,李悦
参考文献(References)：
- [1]Esler M,Rumantir M,Wiesner G,et al.Sympathetic nervous system and insulin resistance:from obesity to diabetes.Am J Hypertens,2001,14:304S-309S.
- [2]DiBona GF.Sympathetic nervous system and the kidney in hypertension.Curr Opin Nephrol Hypertens,2002,11:197-200.
- [3]DiBona GF.Neural control of the kidney:past,present,and future.Hypertension,2003,41:621-624.
- [4]DiBona GF,Esler M.Translational medicine:the antihypertensive effect of renal denervation.Am J Physiol Regul Integr Comp Physiol,2010,298:R245-R253.
- [5]Martin EA,Victor RG.Premise,promise,and potential limitations of invasive devices to treat hypertension.Curr Cardiol Rep,2011,13:86-92.
- [6]Krum H,Schlaich M,Whitbourn R,et al.Catheter-based renal sympathetic denervation for resistant hypertension:a multicentre safety and proof-of-principle cohort study.Lancet,2009,373:1275-1281.
- [7]Esler MD,Krum H,Sobotka PA,et al.Renal sympathetic denervation in patients with treatment-resistant hypertension(The Symplicity HTN-2 Trial):a randomised controlled trial.Lancet,2010,376:1903-1909.
- [8]Katholi RE,Rocha-Singh KJ,Goswami NJ,et al.Renal nerves in the maintenance of hypertension:a potential therapeutic target.Curr Hypertens Rep,2010,12:196-204.
- [9]Mahfoud F,Schlaich M,Kindermann I,et al.Effect of Renal Sympathetic Denervation on Glucose Metabolism in Patients With Resistant Hypertension:A Pilot Study.Circulation,2011,123:1940-1946.
- [10]Doumas M,Douma S.Renal sympathetic denervation:the jury is still out.Lancet,2010,376(9756):1878-1880.
- [11]Gewirtz JR,Bisognano JD.Catheter-based renal sympathetic denervation:A targeted approach to resistant hypertension.Cardiol J,2011,18:97-102.
- [12]Voskuil M,Verloop WL,Blankestijn PJ,et al.Percutaneous renal denervation for the treatment of resistant essential hypertension;the first Dutch experience.Neth Heart J,2011.[Epub ahead of print]
- [13]Doumas M,Faselis C,Papademetriou V.Renal sympathetic denervation and systemic hypertension.Am J Cardiol,2010,105:570-576.