肾动脉支架术治疗肾动脉狭窄的长期疗效Long term outcomes of percutaneous renal interventional therapy in patients with severe renal artery stenosis
倪钧,张瑞岩,胡健,张宪,郑爱芳,沈卫峰
摘要(Abstract):
目的评价肾动脉支架术治疗肾动脉狭窄的长期疗效。方法连续134例显著肾动脉狭窄患者接受肾动脉支架术。记录患者术前、术后24小时、1年和2年的血清肌酐和血压变化情况。结果134例患者均成功置入支架,术后24小时肌酐较术前升高[(109.8±24.6)μmolL比(99.4±27.8)μmolL],肾小球滤过率较术前降低[(57.6±19.3)mLmin比(68.5±18.9)mLmin],但术后1年和2年的平均肌酐和术前比较差异无统计学意义。肾动脉介入治疗术后6个月,64例血压得到改善,其平均血压为(148.6±22.6)mmHg(1mmHg=0.133kPa),与术前比较差异有统计学意义。术后1年和2年分别有56例(50.9%)和50例(49.6%)患者获益。结论肾动脉支架术治疗肾动脉狭窄的远期疗效较好,且长期随访结果满意。
关键词(KeyWords): 动脉硬化;肾动脉梗阻;支架
基金项目(Foundation):
作者(Author): 倪钧,张瑞岩,胡健,张宪,郑爱芳,沈卫峰
参考文献(References):
- 1BullerCE,NogaredaJG,RamanathanK,etal.Theprofileofcardiac patientswithrenalarterystenosis.JAmcollCardiol,2004,43,16061613.
- 2倪钧,沈卫峰,张瑞岩,等.冠心病患者肾动脉介入治疗后尿微球蛋白变化.中华内科杂志,2004,43:2225.
- 3RundbackJH,SacksD,KentKC,etal.Guidelinesforthereporting ofrenalarteryrevascularizationinclinicaltrials.Circulation,2002,106:15721585.
- 4LeetouwerTC,GussenhovenEJ,vanJaarsveldBC,etal.Stent placementforrenalarterialstenosis:wheredowestand?Ameta analysis.Radiology,2000,216:7885.
- 5ChadeAR,LermanA,LermanLO,etal.Kidneyinearly atherosclerosis.Hypertension,2005,45:10421049.
- 6ZellerT,FrankU,MullerC,etal.Stent supportedangioplastysevere atheroscleroticrenalarterystenosispreservesrenalfunctionand improvesbloodpressurecontrol:long termresultsfromaprospective registryof456lesions.JEndovasTher,2004,11:95106.
- 7ZellerT,FrankU,MullerF,etal.Predictorofimprovedrenal functionafterpercutaneousstent supportedangioplastyofsevere atheroscleroticostialrenalarterystenosis.Circulation,2003,108:22442249.
- 8KanwarSG,RichardCF.Atheroscleroticrenalarterialstenosis:clinicaloutcomesofstentplacementforhypertensionandrenalfailure.Radiology,2003,226:821826.
- 9倪钧,沈卫峰,张瑞岩,等.血清肌酐异常病人肾动脉介入治疗的疗效和安全性.中国介入心脏病学杂志,2003,6:290292.