尿激酶与链激酶溶栓治疗急性心肌梗塞疗效比较Comparison of the efficacies of thrombolytic therapy on acute myocardial infarction between with urokinase and streptokinase
崔亮,顼志敏,胡大一,徐琳
摘要(Abstract):
为总结我院两年来静脉溶栓治疗急性心肌梗塞(AMI)之临床经验。收集1994年2月以来,我院CCU接受静脉溶栓治疗的AMI患者共200例,其中用尿激酶(天普洛欣)119例,链激酶81例。结果:两组临床疗效,即血管再通率、5周病死率相近,两药同样安全、有效。副作用中,皮肤粘膜轻度出血率相近,但键激酶的一过性低血压为高(12.3%比0.84%,P<0.001)。结论:两药治疗AMI同样安全有效。
关键词(KeyWords): 急性心肌梗塞;溶栓治疗;链激酶;尿激酶
基金项目(Foundation):
作者(Author): 崔亮,顼志敏,胡大一,徐琳
参考文献(References):
- 1FTT Collaborative Group.Indications for fibrinolytic therapy in suspeted acute myocardial infarction;collaborativeoverview of early mortality and major corbidity results fromall randomized trials of more than 1 000 patiens.Lancet,1994,343:311
- 2链激酶多中心临床试验协作组.急性心肌梗塞链激酶静脉溶栓疗法的多中心试验.中华心血管病杂志,1994,22:403.
- 3The GUSTO Invertigators.An international randomizedtrial comparing four thrombolytic strategies for acute myocardial infarction. N Engl J Med,1993,329:673.
- 4 Agnelli G.Thrombolytic and antithrombotic treatment inmyocardial infarction:main achivements and future perspectives. Int J Cardiol,1995,49(suppl):s77.