米树华,杨秀秀,陶红,王羲之,包柄楠,周芸,郑虹,吴学思

• 1:首都医科大学附属北京安贞医院心内科

摘要(Abstract)：

目的探讨血清脂联素(APN)水平与冠心病及其病变严重程度的相关性。方法选取135例行冠状动脉造影的患者,分别按Gensini积分、冠状动脉病变数目及临床诊断分组,进行血清APN测定。结果Gensini积分0分组(74.53±30.76ng/mL)和<20分组(62.99±26.51ng/mL)APN水平分别显著高于20～40分组(44.06±15.18ng/mL)和>40分组(28.96±11.87ng/mL),P均<0.01。20～40分组APN水平高于>40分组(P<0.05)。APN水平与Gensini积分的对数呈负相关(r=-0.556,P<0.001)。对照组APN水平显著高于单支、双支和三支病变组(74.14±29.48ng/mL比55.29±23.40ng/mL、49.31±25.61ng/mL和38.39±15.57ng/mL,P均<0.01),单支病变组APN水平显著高于三支病变组(P<0.01)。急性冠状动脉综合征组APN水平显著低于非冠心病组和稳定型心绞痛组(47.59±23.57ng/mL比67.05±31.53ng/mL、62.29±26.62ng/mL,P<0.01和P<0.05)。结论APN与冠状动脉狭窄程度、范围以及稳定性显著相关,有助于临床评价冠心病病变程度及其进展。

关键词(KeyWords)： 冠状动脉疾病;脂联素;统计学

Abstract:

Keywords:

基金项目(Foundation): 首都医科大学基础-临床合作研究基金(03JL38)

作者(Author): 米树华,杨秀秀,陶红,王羲之,包柄楠,周芸,郑虹,吴学思

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