卵圆孔未闭伴偏头痛患者111例介入封堵术后短期内血小板相关指标与头痛缓解情况的观察分析Observation analysis of platelet related indexes and headache relief conditions in 111 cases of patent foramen ovale patients with migraine in the short term after interventional occlusion
孙战风,张刚成,张宏伟,金博文
摘要(Abstract)：
目的探讨血小板对卵圆孔未闭(PFO)伴偏头痛患者的影响及对介入封堵术疗效评价的影响。方法选取武汉亚洲心脏病医院2017年1—12月收治的PFO伴偏头痛并行介入封堵术的成年患者111例作为研究对象,对全部患者进行规范抗凝及抗血小板治疗,并于术后1个月进行随访。观察患者手术前后血小板相关指标[血小板计数(PLT)、血小板压积(PCT)、平均血小板体积(MPV)及血小板分布宽度(PDW)]的变化。同时依据介入封堵术后1个月症状是否缓解将患者分为缓解组(67例)和未缓解组(44例),比较两组手术前后血小板相关指标的差异。结果介入封堵术后1个月,所有患者PLT[(204.51±50.31)×10~9/L比(179.61±39.43)×10~9/L,P<0.001]、PCT[(0.18±0.04)%比(0.16±0.03)%,P<0.001]、MPV[(9.93±1.51)fl比(9.48±1.48)fl,P=0.027]、PDW[(17.14±0.55)fl比(15.81±0.95)fl,P<0.001]均较介入封堵术前显著降低,差异均有统计学意义。封堵术后1个月,缓解组患者PDW[(15.48±0.89)fl比(16.31±0.83)fl,P<0.001]明显低于未缓解组,差异有统计学意义。结论介入封堵术后,患者偏头痛症状有效缓解,同时PLT、PCT、MPV、PDW均得到下降。
关键词(KeyWords)： 卵圆孔未闭;偏头痛;血小板
基金项目(Foundation):
作者(Author): 孙战风,张刚成,张宏伟,金博文
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