经皮冠状动脉腔内支架植入术后血小板L-精氨酸/一氧化氮途径的变化Change of the L-Arginine/Nitric Oxide Pathway of Platelet after Coronary Artery Stent Implantation
张宝娓,苏加林,李夏,霍勇,高炜,姚星海,王军,唐朝枢,刘乃奎,丁文惠,朱国英
摘要(Abstract)：
通过观察冠心病人PTCA支架植入术后血小板一氧化氮（NO）生成、NO合酶（NOS）活性和L-精氨酸（L－Arg）转运的变化，探讨PTCA支架术后血小板功能受损的机制。方法：正常对照组14例，其中男8例，女6例，平均年龄52．6±5．5岁；冠心病组11例，其中男9例，女2例，平均年龄53．3±4．8岁。对照组、冠心病组术前及术后不同时期分别取血测定血小板NO生成、NOS活性及L－Arg转运。结果显示：冠心病患者术前血小板NO生成、NOS活性及L－Arg转运明显低于正常对照组，且于术后即刻进一步下降（P＜0．01）；之后有所恢复，但至术后第6天仍未恢复正常（P＜0．05）。意义：PTCA支架术可能通过降低血小板NO合酶活性和L－Arg转运使血小板NO生成减少，此可能是术后血小板粘附聚集的原因之一。
关键词(KeyWords)： 支架;血小板;一氧化氮
基金项目(Foundation):
作者(Author): 张宝娓,苏加林,李夏,霍勇,高炜,姚星海,王军,唐朝枢,刘乃奎,丁文惠,朱国英
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