支气管扩张症伴咯血的血管介入治疗疗效及其复发相关危险因素分析Vascular interventional therapy of bronchiectasis with hemoptysis and its related risk factors for recurrence
朱紫阳,覃伟,余伟,王子鸣,陈莹,刘恩红,李发久,李承红
摘要(Abstract):
目的探讨支气管动脉栓塞术(BAE)治疗支气管扩张症伴咯血中的应用及其复发相关危险因素。方法选取2018年1月至2018年12月在江汉大学附属医院呼吸与危重症医学科行BAE的咯血患者共153例,术后随访2年,主要终点为咯血复发;对患者基线资料、介入治疗措施进行分析,并进行logistic多因素回归分析,探讨支气管扩张症患者咯血行BAE后的复发危险因素。结果 153例患者平均年龄(63±15)岁,男性99例,占比64.7%,既往主要合并高血压病51例(33.3%)、肺结核43例(28.1%)和糖尿病21例(13.7%),37例(24.2%)患者有吸烟史;153例中有16例在2年内复发咯血,复发率为10.5%。153例患者平均有(2±2)支非支气管性体动脉存在异常,复发组平均有(6±4)支非支气管性体动脉异常,明显高于未复发组(P<0.001)。54例(35.3%)介入手术时同台运用支气管镜介入,其中未复发组有52例(38.0%),复发组2例(12.5%)。logistic多因素分析提示:异常非支气管性体动脉数量多是咯血复发的危险因素(OR 1.529,95%CI 1.226~1.907,P<0.001),而双介入治疗是咯血复发的保护性因素(OR 0.071,95%CI 0.009~0.533,P=0.010)。结论 BAE是治疗支气管扩张伴咯血的有效的手段。靶血管越复杂,术后越容易复发。双介入的运用可降低BAE术后咯血的复发,值得在临床广泛推广。
关键词(KeyWords): 咯血;支气管动脉栓塞术;复发;危险因素
基金项目(Foundation): 湖北省卫生健康委基金项目(WJ2019F003);; 武汉市卫生健康委基金项目(WX18D04)
作者(Author): 朱紫阳,覃伟,余伟,王子鸣,陈莹,刘恩红,李发久,李承红
参考文献(References):
- [1]Flume PA,Chalmers JD,Olivier KN.Advances in bronchiectasis:endotyping,genetics,microbiome,and disease heterogeneity.Lancet,2018,392(10150):880-890.
- [2]McDonald DM.Angiogenesis and remodeling of airway vasculature in chronic infl ammation.Am J Respir Crit Care Med,2001,164(10 Pt 2):S39-S45.
- [3]成人支气管扩张症诊疗专家共识编写组.成人支气管扩张症诊治专家共识.中华结核和呼吸杂志,2012,35(7):485-492.
- [4]Kathuria H,Hollingsworth HM,Vilvendhan R,et al.Management of life-threatening hemoptysis.J Intensive Care,2020,8:23.
- [5]Remy J,Voisin C,Dupuis C,et al.Treatment of hemoptysis by embolization of the systemic circulation.Ann Radiol(Paris),1974,17(1):5-16.
- [6]Miyano Y,Kanzaki M,Onuki T.Bronchial artery embolization:fi rst-line option for managing massive hemoptysis.Asian Cardiovasc Thorac Ann,2017,25(9):618-622.
- [7]Maleux G,Matton T,Laenen A,et al.Safety and effi cacy of repeat embolization for recurrent hemoptysis:A 16-year retrospective study including 223 patients.J Vasc Interv Radiol,2018,29(4):502-509.
- [8]Davidson K,Shojaee S.Managing massive hemoptysis.Chest,2020,157(1):77-88.
- [9]Lee BR,Yu JY,Ban HJ,et al.Analysis of patients with hemoptysis in a tertiary referral hospital.Tuberc Respir Dis(Seoul),2012,73(2):107-114.
- [10]Reechaipichitkul W,Latong S.Etiology and treatment outcomes of massive hemoptysis.Southeast Asian J Trop Med Public Health,2005,36(2):474-480.
- [11]Fruchter O,Schneer S,Rusanov V,et al.Bronchial artery embolization for massive hemoptysis:long-term follow-up.Asian Cardiovasc Thorac Ann,2015,23(1):55-60.
- [12]Yoon YC,Lee KS,Jeong YJ,et al.Hemoptysis:bronchial and nonbronchial systemic arteries at 16-detector row CT.Radiology,2005,234(1):292-298.
- [13]Panda A,Bhalla AS,Goyal A.Bronchial artery embolization in hemoptysis:a systematic review.Diagn Interv Radiol,2017,23(4):307-317.