冠状动脉有创功能学检查研究进展Invasive physiological assessment of coronary lesions
曹成富,马玉良,李琪,王伟民
摘要(Abstract):
在当代冠状动脉介入治疗时代,冠状动脉的功能学评估是一项必不可少的工作。然而,尽管有大量循证医学证据及指南推荐冠状动脉的功能学评估在介入治疗中的作用,但在目前的临床实践中冠状动脉功能学评估仍然没有得到充分的利用。除血流储备分数外,各种有创非充血压力比值、CT冠状动脉血流储备分数等无创功能学评价指标不断出现,基于腔内影像学的冠状动脉计算生理学实现了影像学和功能学检查的完美融合。近年来,冠状动脉功能学检查技术蓬勃发展。本文概述了该领域的最新研究进展。
关键词(KeyWords): 血流储备分数;介入治疗;非充血压力比值
基金项目(Foundation): 国家自然科学基金(81800316)
作者(Author): 曹成富,马玉良,李琪,王伟民
参考文献(References):
- [1] Pijls NHJ, van schaardenburgh P, Manoharan G, et al. Percutaneous coronary intervention of functionally nonsignifi cant stenosis:5-year follow-up of the DeFer study. J Am Coll Cardiol, 2007, 49(21):2105-2111.
- [2] Tonino PAL, Fearon WF, De Bruyne B, et al. Angiographic versus functional severity of coronary artery stenoses in the fame study fractional flow reserve versus angiography in multivessel evaluation.J Am Coll Cardiol, 2010, 55(25):2816-2821.
- [3] Fearon WF, Nishi T, De Bruyne B, et al. clinical outcomes and cost-effectiveness of fractional flow reserve-guided percutaneous coronary intervention in patients with stable coronary artery disease:three-year follow-up of the fame 2 trial(fractional flow reserve versus angiography for multivessel evaluation). Circulation, 2018,137(5):480-487.
- [4] Hennigan B, Berry C, Collison D, et al. Percutaneous coronary intervention versus medical therapy in patients with angina and grey-zone fractional flow reserve values:a randomised clinical trial.Heart, 2020, 106(10):758-764.
- [5] Sheth T, Pinilla-Echeverri N, Moreno R, et al. Nonculprit lesion severity and outcome of revascularization in patients with STEMI and multivessel coronary disease. J Am Coll Cardiol, 2020. 76(11):1277-1286.
- [6] Engstr?m T, Kelb?k H, Helqvist S, et al. Complete revascularisation versus treatment of the culprit lesion only in patients with ST-segment elevation myocardial infarction and multivessel disease(DANAMI-3–PRIMULTI):an open-label, randomised controlled trial. Lancet,2015, 386(9994):665-671.
- [7] Smits PC, Laforgia PL, Abdel-Wahab M, et al. Fractional flow reserve-guided multivessel angioplasty in myocardial infarction:three-year follow-up with cost benefi t analysis of the Compare-Acute trial. EuroIntervention, 2020, 16(3):225-232.
- [8] Davies JE, Sen S, Dehbi HM, et al. Use of the instantaneous wavefree ratio or fractional flow reserve in. N Engl J Med, 2017, 376(19):1824-1834.
- [9] G?tberg M, Christiansen EH, Gudmundsdottir IJ, et al. Instantaneous wave-free ratio versus fractional flow reserve to guide. N Engl J Med,2017, 376(19):1813-1823.
- [10] Thim T, G?tberg M, Fr?bert O, et al. Instantaneous wave-free ratio cutoff values for nonculprit stenosis classifi cation in patients with STsegment elevation myocardial infarction(an iSTEMI substudy).Coron Artery Dis, 2020, 31(5):411-416.
- [11] Lee JM, Choi KH, Koo BK, et al. Comparison of major adverse cardiac events between instantaneous wave-free ratio and fractional flow reserve-guided strategy in patients with or without type 2diabetes:a secondary analysis of a randomized clinical trial. JAMA Cardiol, 2019, 4(9):857-864.
- [12] De Salvatore R, Polimeni A, De Giovanni V, et al. Reliability of instantaneous wave-free ratio(i FR)for the evaluation of left main coronary artery lesions. J Clin Med, 2019, 8(8):1143.
- [13] Neumann FJ, Sousa-Uva M, Ahlsson A, et al. 2018 ESC/EACTS guidelines on myocardial revascularization. Eur Heart J, 2019, 40(2):87-165.
- [14] Leone AM, Arioti M, Cialdella P, et al. Prognostic impact of FFR/contrast FFR discordance. Int J Cardiol, 2021, 327:40-44.
- [15] Tu S, Westra J, Yang J, et al. Diagnostic accuracy of fast computational approaches to derive fractional flow reserve from diagnostic coronary angiography:the international multicenter FAVOR pilot study. JACC Cardiovasc Interv, 2016, 9(19):2024-2035.
- [16] Westra J, Andersen BK, Campo G, et al. Diagnostic performance of in-procedure angiography-derived quantitative flow reserve compared to pressure-derived fractional flow reserve:the FAVORⅡEurope-Japan study. J Am Heart Assoc, 2018, 7(14):e009603.
- [17] Tebaldi M, Biscaglia S, Erriquez A, et al. Comparison of quantitative flow ratio, Pd/Pa and diastolic hyperemia-free ratio versus fractional flow reserve in non-culprit lesion of patients with non ST-segment elevation myocardial infarction. Catheter Cardiovasc Interv, 2020.[Online ahead of print]
- [18] Svanerud J, Ahn JM, Jeremias A, et al. Validation of a novel nonhyperaemic index of coronary artery stenosis severity:the resting full-cycle ratio(VALIDATE RFR)study. EuroIntervention, 2018,14(7):806-814.
- [19] Cerrato E, Tomassini F, Salinas P, et al. Simplified hybrid algorithms for pressure wire interrogation exploiting advantages of a baseline and contrast Pd/Pa ratio indexes to predict stenosis signifi cance:Insight from the SPARE multicenter prospective study.Catheter Cardiovasc Interv, 2018, 92(6):1090-1096.
- [20] Burzotta F, Leone AM, Aurigemma C, et al. Fractional flow reserve or optical coherence tomography to guide management of angiographically intermediate coronary stenosis. JACC Cardiovasc Interv, 2020, 13(1):49-58.
- [21] Iannaccone M, Abdirashid M, Annone U, et al. Comparison between functional and intravascular imaging approaches guiding percutaneous coronary intervention:A network meta-analysis of randomized and propensity matching studies. Catheter Cardiovasc Interv, 2020, 95(7):1259-1266.
- [22] Kennedy MW, Fabris E, Ijsselmuiden AJ, et al. Combined optical coherence tomography morphologic and fractional flow reserve hemodynamic assessment of non-culprit lesions to better predict adverse event outcomes in diabetes mellitus patients:COMBINE(OCT-FFR)prospective study. Rationale and design. Cardiovasc Diabetol, 2016, 15(1):144.
- [23] Huang J, Emori H, Ding D, et al. Diagnostic performance of intracoronary optical coherence tomography-based versus angiography-based fractional flow reserve for the evaluation of coronary lesions. EuroIntervention, 2020, 16(7):568-576.
- [24] Bezerra CG, Hideo-Kajita A, Bulant CA, et al. Coronary fractional flow reserve derived from intravascular ultrasound imaging:validation of a new computational method of fusion between anatomy and physiology. Catheter Cardiovasc Interv, 2019, 93(2):266-274.
- [25] Di Gioia G, De Bruyne B, Pellicano M, et al. Fractional flow reserve in patients with reduced ejection fraction. Eur Heart J,2020, 41(17):1665-1672.
- [26] Thakur U, Khav N, Comella A, et al. Fractional flow reserve following percutaneous coronary intervention. J Interv Cardiol,2020, 2020:7467943.
- [27]冠状动脉血流储备分数临床该应用专家共识组.冠状动脉血流储备分数临床应用专家共识.中华心血管病杂志,2016,44(4):292-297.
- [28] Wolfrum M, De Maria GL, Benenati S, et al. What are the causes of a suboptimal FFR after coronary stent deployment? Insights from a consecutive series using OCT imaging. EuroIntervention, 2018, 14(12):e1324-e1331.
- [29] van Bommel RJ, Masdjedi K, Diletti R, et al. Routine fractional flow reserve measurement after percutaneous coronary intervention.Circ Cardiovasc Interv, 2019, 12(5):e007428.
- [30] Jeremias A, Davies JE, Maehara A, et al. Blinded physiological assessment of residual ischemia after successful angiographic percutaneous coronary intervention. JACC Cardiovasc Interv, 2019,12(20):1991-2001.
- [31] Shin D, Lee SH, Lee JM, et al. Prognostic implications of postintervention resting Pd/Pa and fractional flow reserve in patients with stent implantation. JACC Cardiovasc Interv, 2020, 13(16):1920-1933.
- [32] Lee JM, Hwang D, Choi KH, et al. Prognostic implications of relative increase and fi nal fractional flow reserve in patients with stent implantation. JACC Cardiovasc Interv, 2018, 11(20):2099-2109.
- [33] van Zandvoort LJ, Masdjedi K, Witberg K, et al. Explanation of postprocedural fractional flow reserve below 0.85. Circ Cardiovasc Interv, 2019, 12(2):e007030.
- [34] Van Herck PL, Carlier SG, Claeys MJ, et al. Coronary microvascular dysfunction after myocardial infarction:increased coronary zero flow pressure both in the infarcted and in the remote myocardium is mainly related to left ventricular fi lling pressure. Heart, 2007, 93(10):1231-1237.
- [35] Samady H, Lepper W, Powers ER, et al. Fractional flow reserve of infarctrelated arteries identifi es reversible defects on noninvasive myocardial perfusion imaging early after myocardial infarction. J Am Coll Cardiol, 2006, 47(11):2187-2193.
- [36] Sorajja P, Gersh BJ, Cox DA, et al. Impact of multivessel disease on reperfusion success and clinical outcomes in patients undergoing primary percutaneous coronary intervention for acute myocardial infarction. Eur Heart J, 2007, 28(14):1709-1716.
- [37] Belle EV, Baptista SB, Raposo L, et al. Impact of routine fractional flow reserve on management decision and 1-year clinical outcome of patients with acute coronary syndromes:PRIME-FFR(insights from the POST-IT[portuguese study on the evaluation of FFRguided treatment of coronary disease] and R3F[french FFR registry] integrated multicenter registries-implementation of FFR[fractional flow reserve] in routine practice). Circ Cardiovasc Interv, 2017, 10(6):e004296.
- [38] Omran J, Enezate T, Abdullah O. Outcomes of fractional flow reserve-guided percutaneous coronary interventions in patients with acute coronary syndrome. Catheter Cardiovasc Interv, 2020, 96(2):E149-E154.
- [39] Smits PC, Abdel-Wahab M, Neumann FJ, et al. Fractional flow reserve–guided multivessel angioplasty in myocardial infarction. N Engl J Med, 2017, 376(13):1234-1244.
- [40] Mehta SR, Wood DA, Storey RF. Complete revascularization with multivessel for myocardial infarction. N Engl J Med, 2019, 381(15):1411-1421.
- [41] L?nborg J, Engstr?m T, Kelb?k H. Fractional flow reserve–guided complete revascularization improves the prognosis in patients with ST-segment-elevation myocardial infarction and severe nonculprit disease a DANAMI 3-PRIMULTI substudy(primary in patients with ST-elevation myocardial infarction and multivessel disease:treatment of culprit lesion only or complete revascularization. Circ Cardiovasc Interv, 2017, 10(4):e004460.
- [42] Lee JM, Choi KH, Koo BK, et al. Prognosis of deferred nonculprit lesions according to fractional flow reserve in patients with acute coronary syndrome. EuroIntervention, 2017, 13(9):e1112-e1119.
- [43] Cerrato E, Mejía-Rentería H, Dehbi HM, et al. Revascularization deferral of nonculprit stenoses on the basis of fractional flow reserve:1-year outcomes of 8,579 patients. JACC Cardiovasc Interv, 2020, 13(16):1894-1903.
- [44] Escaned J, Ryan N, Mejía-Rentería H, et al. Safety of the deferral of coronary revascularization on the basis of instantaneous wave-free ratio and fractional flow reserve measurements in stable coronary artery disease and acute coronary syndromes. JACC Cardiovasc Interv, 2018, 11(15):1437-1449.
- [45] Jayakumar S, Bilkhu R, Ayis S, et al. The role of fractional flow reserve in coronary artery bypass graft surgery:a meta-analysis.Interact Cardiovasc Thorac Surg, 2020, 30(5):671-678.
- [46] Fournier S, Toth GG, De Bruyne B, et al. Six-year follow-up of fractional flow reserve-guided versus angiography-guided coronary artery bypass graft surgery. Circ Cardiovasc Interv, 2018, 11(6):e006368.
- [47] Wada T, Shiono Y, Kubo T, et al. Impact of instantaneous wavefree ratio on graft failure after coronary artery bypass graft surgery.Int J Cardiol, 2021, 324:23-29.
- [48] Toth GG, De Bruyne B, Kala P, et al. Graft patency after FFRguided versus angiography-guided coronary artery bypass grafting:the GRAFFITI trial. EuroIntervention, 2019, 15(11):e999-e1005.