新型冠状病毒肺炎对区域协同救治体系下急性ST段抬高型心肌梗死患者行直接经皮冠状动脉介入治疗的影响Effect of COVID-19 on direct percutaneous coronary intervention in patients with acute ST-segment elevation myocardial infarction under regional cooperative treatment system
彭倬,杨丽霞,石燕昆,陈宇,陈长征,杨梅
摘要(Abstract):
目的研究新型冠状病毒肺炎(COVID-19)疫情期间,疫情防控对急性ST段抬高型心肌梗死(STEMI)患者诊疗的影响。方法纳入2020年1月25日至2020年5月25日就诊于解放军联勤保障部队第九二〇医院心内科并成功行直接经皮冠状动脉介入治疗(PPCI)的80例患者为研究组,选取2019年同期行PPCI的STEMI患者130例作为对照组。收集患者的临床资料,对比两组患者一般临床资料、胸痛中心急诊手术再灌注时间点、术后30 d主要不良心脑血管事件(MACCE)及超声心动图结果。结果研究组与对照组相比,首次医疗接触至球囊扩张时间[198.5(134.25,314.00)min比161.5(101.80,228.50)min,P=0.022]、发病至首次医疗接触时间[281.5(90.25,1010.50)min比240.0(80.00,526.25)min,P=0.049]、发病至球囊扩张时间[600.5(318.25,1293.75)min比401.5(237.25,794.00)min,P=0.019]均延长,且差异均有统计学意义。两组患者术后30 d心原性死亡、非致死性心肌梗死或靶血管再次血运重建、非致死性卒中的发生率比较,差异均无统计学意义(均P>0.05)。但与对照组相比,术后30 d左心室舒张末期内径[(47.66±5.52)mm比(46.15±5.15)mm,P=0.046]、MACCE发生率(10.0%比5.4%,P<0.001)增加,左心室射血分数[(43.89±6.55)%比(45.66±4.97)%,P=0.029]降低,差异均有统计学意义。结论受COVID-19疫情的影响,STEMI患者发病就诊时间明显延迟,首次医疗接触到术前的时间延长,术后30 d的MACCE发生率增高,心功能下降,患者预后较常规时期差。应在防控疫情的同时,进一步优化STEMI就诊流程,减少院前及院内时间的延迟,使胸痛中心如常态化高效、有序运作。
关键词(KeyWords): 急性心肌梗死;新型冠状病毒肺炎;胸痛中心;直接经皮冠状动脉介入治疗;再灌注
基金项目(Foundation):
作者(Author): 彭倬,杨丽霞,石燕昆,陈宇,陈长征,杨梅
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