孙千惠,张露露,王思雯,饶子鸣,朱达

• 1:云南省阜外心血管病医院结构性心脏病病区
• 2:大理大学临床医学院

摘要(Abstract)：

二尖瓣反流是一种常见的瓣膜性心脏病，随着人口老龄化的发展，二尖瓣反流且高龄患者数量在逐渐增加，由于存在较高的手术风险，仅部分患者适合接受传统外科手术治疗。近年来，经导管二尖瓣缘对缘修复术（TEER）已成为治疗二尖瓣反流的重要方式之一。但退行性二尖瓣反流合并瓣环钙化，依旧是TEER适应证的边界及难点。本病例报道1例采用国产NeoNova~??经导管二尖瓣缘对缘修复装置治疗退行性二尖瓣反流伴后瓣环钙化的高龄患者的成功经验，为临床治疗退行性二尖瓣反流合并瓣环钙化的高龄患者提供一定的参考。

关键词(KeyWords)： 退行性二尖瓣反流;经导管二尖瓣缘对缘修复术;国产器械

Abstract:

Keywords:

基金项目(Foundation): 云南省重大科技专项计划项目(202302AA310045);; 云南省科技人才与平台计划项目(202305AF150069)

作者(Author): 孙千惠,张露露,王思雯,饶子鸣,朱达

参考文献(References)：

• [1]Yang Y,Wang Z,Chen Z,et al.Current status and etiology of valvular heart disease in China:a population-based survey[J].BMC Cardiovasc Disord,2021,21(1):339. DOI:10.1186/s12872-021-02154-8.
• [2]Praz F,Borger MA,Lanz J,et al.2025 ESC/EACTS Guidelines for the management of valvular heart disease[J].Eur Heart J,2025,46(44):4635-4736. DOI:10.1093/eurheartj/ehaf194.
• [3]Feldman T,Kar S,Elmariah S,et al.Randomized comparison of percutaneous repair and surgery for mitral regurgitation:5-year results of EVERESTⅡ[J].J Am Coll Cardiol,2015,66(25):2844-2854.DOI:10.1016/j.jacc.2015.10.018.
• [4]Obadia JF,Messika-Zeitoun D,Leurent G,et al.Percutaneous repair or medical treatment for secondary mitral regurgitation[J].N Engl J Med,2018,379(24):2297-2306. DOI:10.1056/NEJMoa1805374.
• [5]Szerlip M,Spargias KS,Makkar R,et al.2-year outcomes for transcatheter repair in patients with mitral regurgitation from the CLASP study[J].JACC Cardiovasc Interv,2021,14(14):1538-1548.DOI:10.1016/j.jcin.2021.04.001.
• [6]Wang J,Liu X,Pu Z,et al.Safety and efficacy of the DragonFly system for transcatheter valve repair of degenerative mitral regurgitation:oneyear results of the DRAGONFLY-DMR trial[J].EuroIntervention,2024,20(4):e239-e249. DOI:10.4244/EIJ-D-23-00361.
• [7]Kar S,Price MJ,Morse MA,et al.Transcatheter repair in posterior,anterior,and bileaflet mitral valve disease[J].JACC Cardiovasc Interv,2025,18(7):898-908. DOI:10.1016/j.jcin.2024.12.023.
• [8]Morikawa T,Enta Y,Sakamoto T,et al.1-year outcomes of fourthgeneration mitral transcatheter edge-to-edge repair in Japan from the EXPAND G4 study[J].JACC Asia,2024,4(11):810-821.DOI:10.1016/j.jacasi.2024.08.003.
• [9]von Bardeleben RS,Mahoney P,Morse MA,et al.1-year outcomes with fourth-generation mitral valve transcatheter edge-toedge repair from the EXPAND G4 study[J].JACC Cardiovasc Interv,2023,16(21):2600-2610. DOI:10.1016/j.jcin.2023.09.029.
• [10]Pazdernik M,Iung B,Mutlu B,et al.Surgery and outcome of infective endocarditis in octogenarians:prospective data from the ESC EORP EURO-ENDO registry[J].Infection,2022,50(5):1191-1202.DOI:10.1007/s15010-022-01792-0.
• [11]Yoon SH,Makar M,Kar S,et al.Outcomes after transcatheter edgeto-edge mitral valve repair according to mitral regurgitation etiology and cardiac remodeling[J].JACC Cardiovasc Interv,2022,15(17):1711-1722. DOI:10.1016/j.jcin.2022.07.004.
• [12]Hausleiter J,Lim DS,Gillam LD,et al.Transcatheter edge-to-edge repair in patients with anatomically complex degenerative mitral regurgitation[J].J Am Coll Cardiol,2023,81(5):431-442. DOI:10.1016/j.jacc.2022.11.034.