耿文磊,胡海波,蒋世良,徐仲英,张戈军,郑宏,赵世华,金敬琳,李世国,吕建华,徐亮,刘琼,万俊义,潘湘斌

• 1:国家心血管病中心北京协和医学院中国医学科学院阜外医院结构性心脏病中心

摘要(Abstract)：

目的分析总结经皮肺动脉瓣球囊扩张术(PBPV)单中心临床应用30年治疗肺动脉瓣狭窄的临床价值及疗效。方法 1986年4月至2016年4月阜外医院共完成1229例PBPV,对其中临床资料完整的655例患者进行了6个月及以上的有效随访,随访时间为0.5～11.5年,平均(2.6±1.3)年,主要随访包括电话随访及门诊随访(以复查超声心动图为主)。结果 1229例患者术后即刻导管测量的跨瓣压差(PG)由术前(74.40±29.64)mmHg下降至(25.05±8.62)mmHg,下降明显(P<0.001),最后1次随访时超声心动图测量的平均PG维持在(21.91±17.22)mm Hg。PBPV成功率达到98.5%(1211/1229),发生术中及围术期死亡3例(死亡率0.2%),其他严重并发症(包括三尖瓣腱索断裂、肺动脉瓣重度反流)发生率为0.4%(5/1229)。超声心动图随访中3.1%(20/655)肺动脉瓣反流程度较术后24 h有所增加,再狭窄发生率为1.1%(7/655)。结论 30年的临床应用经验表明PBPV作为一种主要治疗单纯性肺动脉瓣狭窄的介入技术,其总体近、中、远期疗效满意,并发症发生率低,可作为一项瓣膜病微创治疗时代的主流技术继续应用于临床。

关键词(KeyWords)： 经皮肺动脉瓣球囊扩张术;肺动脉瓣狭窄;球囊成形术

Abstract:

Keywords:

基金项目(Foundation):

作者(Author): 耿文磊,胡海波,蒋世良,徐仲英,张戈军,郑宏,赵世华,金敬琳,李世国,吕建华,徐亮,刘琼,万俊义,潘湘斌

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