骨髓单个核细胞移植和冠状动脉介入治疗后再狭窄关系的实验研究Experimental study on coronary restenosis after bone marrow mononuclear cells transplantation
温尚煜,毛节明,徐晓蓉,李海燕,潘震华,郭艳红,周春燕,高炜
摘要(Abstract)：
目的研究骨髓单个核细胞移植对冠状动脉介入治疗后支架内再狭窄的影响。方法用球囊堵闭法制成小型猪急性前壁心肌梗死模型,喂养3周后在左前降支置入支架,同时提取骨髓分离单个核细胞,注入梗死相关血管。饲养4周后做冠状动脉造影定量分析狭窄程度。对支架两端血管组织学切片做苏木精-伊红和天狼猩红染色分析再狭窄原因。结果实验组8头小型猪中有4头发生再狭窄,再狭窄率为50%;对照组9头中有4头发生再狭窄,再狭窄率为44%,两组间比较差异无统计学意义;冠状动脉造影定量分析提示:骨髓单个核细胞治疗组冠状动脉支架内管腔晚期丢失为1·50±1·45mm,对照组为1·31±1·07mm(P=0·736),两组比较差异无统计学意义。结论在小型猪心肌缺血模型中,骨髓单个核干细胞移植不增加冠状动脉介入治疗后支架内再狭窄发生率。
关键词(KeyWords)： 心肌梗死;骨髓细胞;细胞移植;再狭窄
基金项目(Foundation): “十五”国家科技攻关计划项目(2004BA714B-1)
作者(Author): 温尚煜,毛节明,徐晓蓉,李海燕,潘震华,郭艳红,周春燕,高炜
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