缺血预适应心肌保护作用的临床研究The clinical study of myocardial protection on ischemia by preconditioning
柳景华,任自文,汪丽蕙,张钧华,丁燕生
摘要(Abstract)：
目的 为探讨心绞痛对心肌梗塞后心功能的影响。方法 对 1 4 5例急性心肌梗塞 (AMI)患者临床回顾性分析 ,阐明梗塞前心绞痛 (PAP)对心肌梗塞范围、梗塞后并发症及恶性心律失常等方面所起的作用。结果 PAP组有较少坏死Q波数 (P <0 0 1 )和异常室壁运动个数 (P <0 0 5) ,有显著降低的CK和CK MB峰值 (P <0 0 1 ) ,左室和右室射血分数也较高 (P <0 0 5)。住院期间心功能不全发生率明显下降 ,2 4小时内室性早搏、室性心动过速、室颤和房室传导阻滞发生率明显降低 (P <0 0 1 ) ,而左室高峰充盈率 (LVPFR)和侧支循环相比较无明显差异。提示 :PAP具有缩小心肌梗塞范围 ,保护心脏收缩功能 ,抗恶性心律失常的作用。对心脏舒张功能、房颤、梗塞后心绞痛和室壁瘤等可能无保护作用。
关键词(KeyWords)： 缺血;预适应;心肌保护;心绞痛;心肌梗塞
基金项目(Foundation):
作者(Author): 柳景华,任自文,汪丽蕙,张钧华,丁燕生
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