蔡连卫,程江涛,孙子瑞,郭晓燕,吴艳芳,张晶晶

• 1:阜外华中心血管病医院心内科
• 2:阜外华中心血管病医院冠心病重症监护室

摘要(Abstract)：

目的 总结球囊肺动脉成形术（BPA）治疗不能外科手术的慢性血栓栓塞性肺动脉高压（CTEPH）的疗效和安全性。方法 回顾性分析2018年2月至2021年12月阜外华中心血管病医院19例CTEPH患者因不能行肺动脉血栓内膜剥脱术（PEA）而进行BPA治疗的临床资料，比较BPA治疗前后世界卫生组织（WHO）心功能、肺动脉压力和右心大小的变化。结果 入组患者平均年龄（56.6±12.2）岁，男8例（8/19）；共接受38次BPA治疗。与BPA治疗前相比，BPA后患者的6 min步行试验距离[（418.1±20.6）m比（351.1±33.6）m,P<0.001]和心输出量[（3.9±0.8）L/min比（3.4±1.7）L/min,P=0.048]增加，N末端B型脑钠肽前体[（767.5±149.0）pg/ml比（2 777.5±463.2）pg/ml,P<0.001]、肺血管阻力[（9.4±2.3）Wood单位比（14.4±4.5）Wood单位，P<0.001]和平均肺动脉压[（35.3±1.4）mmHg比（44.8±2.2）mmHg(1mmHg=0.133kPa),P<0.001]下降，右心室基底内径[（25.4±1.0）mm比（30.0±0.9）mm,P<0.001]和右心房左右径[（46.5±1.9）mm比（53.7±1.9）mm,P<0.001]减小，差异均有统计学意义。BPA后共发生4例次（4/38）并发症。结论 对于不能行PEA的CTEPH患者，BPA可有效降低肺动脉压力，改善肺灌注，增加心输出量，且并发症发生率低，是CTEPH患者较为有效的治疗方法之一。

关键词(KeyWords)： 慢性血栓栓塞性肺动脉高压;球囊肺动脉成形术;疗效

Abstract:

Keywords:

基金项目(Foundation):

作者(Author): 蔡连卫,程江涛,孙子瑞,郭晓燕,吴艳芳,张晶晶

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